ΕΠΙΔΡΑΣΗ ΔΙΟΥΡΗΤΙΚΩΝ ΦΑΡΜΑΚΩΝ ΣΤΗ ΝΕΦΡΙΚΗ ΑΠΕΚΚΡΙΣΗ ΤΟΥ ΨΕΥΔΑΡΓΥΡΟΥ

THE EFFECT OF DIURETIC AGENTS ON RENAL ZINC EXCRETION WAS STUDIED BY: A) INFUSING FUROSEMIDE INTRAVENOUSLY (20 MG), ALONE OR IN COMBINATION WITH SODIUM LOADING (INFUSION OF 2 LT ISOTONIC SALINE 24 H BEFORE AND CONCOMITANT INFUSION OF 250 ML ISOTONIC SALINE DURING THE ADMINISTRATION OF FUROSEMIDE) IN 11 HEALTHY VOLUNTEERS AND B) ADMINISTRATION HYDROLLOROTHIARIDE (50 MG DAILY) ALONE OR IN COMBINATION WITH TRIAMTERENE (100 MG DAILY), PEROS FOR 5 WEEKS, IN TWO GROUPS OF A TOTAL NUMBER OF 35 PATIENTS WITH MILD ARTERIAL HYPERTENSIN (DIASTOLIC B.P< 110 MGHG). IT IS CONCLUDED THAT: 1) DIURETIC (EITHER THIARIDE OF LOOP DIURETIC) ADMINISTRATION RESULTS IN INCREASED RENAL ZINC EXCRETION. 2) THE INCREASE IN ZINC EXCRETION DURING DIURETIC ADMINISTRATION CORRESPONDS TO THE INCREASEIN SODIUM EXCRETION AND SUGGEST AN INTERELATIONSHIP BETWEEN THE MECHANISMS INVOLVED IN THE RENAL HANDLING OF THE TWO IONS. 3) CONTINUOUS URINARY ZINC LOSSES DURING CHRONIC DIURETIC TREATMENT WEIGHT RESULT IN ZINC DEPLETION WITH POTENTIAL CLINICAL IMPLICATIONS, ESPECIALLY IN OLDER INDIVIDUALS.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Authors dc:creator

• Dourakis, Spyros
• Ντουράκης, Σπυρίδων

• ΔΙΟΥΡΗΤΙΚΑ ΦΑΡΜΑΚΑ
• ΕΝΔΕΙΑ ΨΕΥΔΑΡΓΥΡΟΥ
• ΝΕΦΡΙΚΗ ΑΝΕΠΑΡΚΕΙΑ ΨΕΥΔΑΡΓΥΡΟΥ
• DIURETIC AGENTS
• RENAL ZINC EXCRETION
• ZINC DEPLETION
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Κλινική Ιατρική
• Medical and Health Sciences
• Basic Medicine
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0415

OAI identifier oai:identifier

oai:10442/0415