Η ΕΠΙΔΡΑΣΙΣ ΤΗΣ ΧΡΟΝΙΑΣ ΧΟΡΗΓΗΣΕΩΣ ΠΡΟΠΡΑΝΟΛΟΛΗΣ ΕΠΙ ΤΟΥ ΒΑΡΟΥΣ ΤΗΣ ΑΡΙΣΤΕΡΑΣ ΚΟΙΛΙΑΣ (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΕΠΙ ΕΠΙΜΥΩΝ)

THE PRESENT STUDY WAS UNDERTAKEN TO INVESTIGATE THE INFLUENCE OF CHRONIC PROPRANOLOL ADMINISTRATION TO GROWING RATS ON LEFT RENTICLE WEIGHT. PROPRANOLOL (100 MG/KG BODY WEIGHT) WAS ADMINISTERED IN THEIR DRINKING WATER TO 124 RATS DIVIDEDINTO EXPERIMENTAL AND CONTROL GROUPS OF BOTH SEXES. ANIMALS WERE SACRIFICED DURING THEIR 17TH WEEK AND THEIR BODY AND HEART WEIGHTS NOTED. MALE HEART WEIGHTSHAD (P<0.05). THE RIGHT RENTRICLE WEIGHT OF BOTH SEXES HAD NO SIGNIFICANT DIFFERENCE BETWEEN GROUPS. THE RATIOS OF ABSOLUTE RIGHT RENTRICLE WEIGHT TO BODY WEIGHT AND TO TOTAL HEART WEIGHT OF BOTH SEXES WAS SIGNIFICANTLY SMALLER. THE RATIO LEFT RENTRICLE WEIGHT/BODY WEIGHT WAS SIGNIFICANTLY LARGER IN EXPERIMENTAL GROUPS OF BOTH SEXES WHEREAS THE RATIO LEFT RENTRICLE/TOTAL HEART WEIGHT WAS SIGNIFICANTLY SMALLER ONLY IN THE FEMALE EXPERIMENTAL GROUP. THE RATIO ABSOLUTE SEPTAL WEIGHT/BODY WEIGHT WAS SIGNIFICANTLY LARGER IN BOTH EXPERIMENTAL GROUPS OFBOTH SEXES. HISTOMETRICAL DETERMINATION OF QUANTITY AND SURFACE OF MUSCULAR CELLS' NUCLEI SHOWED GREATER MEAN NUCLEAR SURFACE IN MALE EXPERIMENTAL GROUP ONLY. SINCE HISTOLOGICAL EXAMINATION SHOWED TO DIFFERENCE INTERCELLULAR CONNECTIVE TISSUE, DECREASED LEFT RENTRICLE WEIGHT MAY BE DUE TO DECREASED VOLUME OF MUSCLE CELL, WHICH MAY BE CAUSED BY COMPLICATED MECHANISMS THROUGH WHICH PROPRANOL DECREASES STROKE VOLUME AND PLASMA VOLUME, INHIBITS REMIN SECRETION AND INCREASES RASODILATOR PROSTAGLANDIN SECRETION. THE ABOVE MECHANISMS DECREASE CARDIAC OUTPUT AND BLOOD PRESSURE WHICH LESSEN THE CARDIAC MUSCLE'S WORK AND CONSEQUENTLYITS WEIGHT.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1985

Author dc:creator

• Ματσίκας, Παντελής

• B-ADRENERGIC BLOCKERS
• Histometric study
• LT VENTRICLE
• Propranolol
• Αριστερή κοιλία
• β-αδρενεργικοί αναστολείς
• ΙΣΤΟΜΕΤΡΙΑ
• Προπρανολόλη
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0331

OAI identifier oai:identifier

oai:10442/0331