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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Propranolol"”.
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The role of propranolol in the treatment of infantile haemangioma
… infantile haemangioma with the introduction of propranolol. The aim of this study is to retrospectively evaluate a simple treatment for infantile haemangioma at the Red Cross War Memorial Children’s Hospital (RCWMCH) and document the results. While it is known that all haemangiomas undergo …
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Propranolol Elicits Long Term Systemic Effects After Repetitive Mild Traumatic Brain Injury
… after injury by injecting the beta blocker propranolol directly after injury and investigating the immune changes in the blood, brain, spleen, and bone marrow of mTBI animals. Together, these data show mTBI causes immune genetic and pathway level changes at least one month after injury and …
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An investigation of propranolol as an agent for the experimental manipulation of interoception.
… drawbacks. We investigated whether 20 mg of propranolol is a viable agent for experimentally manipulating interoception. Thirteen participants completed a double-blind, placebo-controlled crossover study, performing two heartbeat perception tasks, control tasks and measures of anxiety and …
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The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
… blockade with the non-selective -blocker propranolol. Studies over the last several decades have shown benefit of propranolol use in pediatric burned patients, but much is still unknown about the acute metabolic changes related to propranolol and burn injury. In this study we used stable …
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The first-pass extraction of pindolol in comparison with propranolol in rat liver
Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by …
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Performance and characteristics of controlled release matrices composed of hydroxpropylmethylcellulose and other polymers.
… with other adjuncts, to control the release of propranolol hydrochloride from matrices. Gels were characterized by U tube viscometry and their cloud points of gels. The properties of polymers and their mixture in matrices or in gels were investigated by differential scanning calorimetry (DSC). …
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Investigation of the beta 2 adrenergic receptor (B2-AR) pathway in canine hemangiosarcoma
… which includes surgery and chemotherapy. Propranolol, an oral drug originally developed for the treatment of cardiovascular diseases, has been successfully used for the treatment of infantile hemangioma which is a benign neoplasia of vascular endothelial cells. Propranolol blocks …
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Entraver la reconsolidation synaptique à l’aide de propranolol pour traiter la douleur nociplastique : études de faisabilité randomisées contrôlées par placebo chez des participants atteints de lombalgie chronique et de fibromyalgie
… et à bloquer leur reconsolidation à l’aide de propranolol. Objectifs : L’objectif principal de la thèse était d’évaluer la faisabilité d’une version modifiée de la TR pour le traitement de la lombalgie chronique (étude 1) et de la fibromyalgie (étude 2). L’objectif secondaire était d’obtenir …
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The pathophysiological mechanisms underlying metamemory disruptions
… whether blocking noradrenergic action using propranolol would remediate arousal-related disruptions to metamemory performance. It was hypothesised that heightened autonomic arousal would predict disruptions to metacognitive efficiency. I additionally hypothesised that blocking noradrenergic …
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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms
… sustained release oral formulations of a basic (Propranolol HCl) and an acidic drug (Glipizide).</p> <p>Hot melt granulation was used to prepare free-flowing, directly compressible carbopol-wax blends. Evaluation of granular characteristics of carbopol-wax blends indicated that changes in the …
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Η ΕΠΙΔΡΑΣΙΣ ΤΗΣ ΧΡΟΝΙΑΣ ΧΟΡΗΓΗΣΕΩΣ ΠΡΟΠΡΑΝΟΛΟΛΗΣ ΕΠΙ ΤΟΥ ΒΑΡΟΥΣ ΤΗΣ ΑΡΙΣΤΕΡΑΣ ΚΟΙΛΙΑΣ (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΕΠΙ ΕΠΙΜΥΩΝ)
… TO INVESTIGATE THE INFLUENCE OF CHRONIC PROPRANOLOL ADMINISTRATION TO GROWING RATS ON LEFT RENTICLE WEIGHT. PROPRANOLOL (100 MG/KG BODY WEIGHT) WAS ADMINISTERED IN THEIR DRINKING WATER TO 124 RATS DIVIDEDINTO EXPERIMENTAL AND CONTROL GROUPS OF BOTH SEXES. ANIMALS WERE SACRIFICED DURING …
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Light-activated materials for singlet oxygen generation and the degradation of pollutants
… shown to degrade a model pharmaceutical, namely propranolol, along with several semi-volatile and volatile organic pollutants. Specifically, UV- and visible light-activated membranes were synthesized by the simple method of doping a photosensitizer (PS) into a polyurethane substrate, ClearFlex 50 …
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An electrophysiologic investigation of the normal and ischemic left ventricle
… and administration of an anti-arrhythmic drug, propranolol. The occlusion experiments are primarily of a temporary nature in order to study the early effects of acute myocardial ischemia; long term occlusion experiments are also conducted in order to investigate the transition from severe …
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Sympathetic Innervation of the Rat Adrenal Cortex and Its Effects on the Compensatory Adrenal Cortical Growth Response to Unilateral Adrenalectomy (Catecholamine, Endocrine, Splanchnic Nerve, Cell Proliferation)
… in animals treated with the (beta)-blockers propranolol (10 or 25 mg/kg) and Sotalol (25 or 50 mg/kg), although vehicle-injected animals failed to show the response. These results suggested that (beta)-adrenergic receptor blockade released a stress-related inhibition of the compensatory …
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Uptake and transport of orally-deliverable drugs across caco-2 cell monolayers:the effect of lipid formulations
… in vitro. Uptake and transport of mannitol, propranolol, glutamine and digoxin was measured in the presence and absence of Iiposome formulations to establish changes in absorption resulting from the presence of lipid formulations. Incorporation of the four hydroxybenzoates was shown to be …
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Sublingual drug delivery: In vitro-in vivo correlation
… (1.91±0.44)×10 –5 , (2.34±0.26)×10 –5 ; Propranolol: (2.93±0.52)×10 –5 , (3.51±0.75)×10 –5 ; Verapamil: (3.95±0.29)×10 –5 , (4.75±0.81)×10 –5 and Atenolol: (2.01±0.68)×10 –6 , (2.95±0.32)×10 –6 cm/s, respectively (p>0.05). The discrepancy between in vitro and in vivo system was …
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Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos
… data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding …
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Application of capillary zone electrophoresis methods for the investigation of in vitro drug metabolism.
… for both a series of basic analogues including propranolol and an acidic compound, chlorogenic acid. A novel approach to the CZE method development for the acid was a statistical analysis technique called Factorial Experimental Design (FED), which allowed the time-saving, simultaneous evaluation …
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Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
… the <em>in vivo</em> effects of a β-blocker, propranolol, and HPV E6/E7 siRNA. <em>In vitro</em>, ADRβ positive cervical cancer cells were treated with norepinephrine (NE) or isoproterenol (ISO) to examine intracellular responses. Invasion and anoikis assays were performed to elucidate the …
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