ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού

Βλάσσης, Θεόδωρος

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National and Kapodistrian University of Athens

ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού

dc:creator Βλάσσης, Θεόδωρος

dc:date1985

Abstract

dc:description

TRYING TO ORGANIZE AS BETTER AS WE COULD OUR TISSUE TYPING LABORATORY WE STARTED ON COLLECTING SERA OF MULTIPOROUS WOMEN. SCREENING 306 SERA SAMPLES WE HAVEFOUND THAT 50 OF THOSE WOMEN (16.33%) WERE SENSITIZED AGAINST THEIR CHILDREN AND THAT PERCENTAGE SENSITIZATION INCREASES WITH INCREASING NUMBER OF PREGNANCIES. OUR TECHNIQUE WAS BASED PRIMARILY ON DIRECT AUTOTOXICITY OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE VERY LOW PERCENTAGE OF SENSITIZATION IN MOTHERS WITH B BLOOD GROUP. FURTHERMORE IT SEEMS THAT THERE IS A DIFFERENCE IN IMMUNOGENICITY BETWEEN HLA ANTIGENS IN FETO-MATERNAL RELATIONSHIP. SO HLA-B ANTIGENS ARE MORE FREQUENT IMMUNOGENIC AS COMPARED WITH ANTIGENS OF THE OTHER LOCI (A, DR, G). IN OUR SERIES HLA-BW22, B15 AND B27 WERE FOUND, AS JUDGED BY A RATIO OF IMMUNOGENICITY TO THE MOST POTENT ANTIGENS.

Degree

thesis:*

Grantor dc:publisher: National and Kapodistrian University of Athens
Year dc:date: 1985

Author and committee

dc:creator, dc:contributor.*

Author dc:creator: Βλάσσης, Θεόδωρος

Subjects

dc:subject × 15

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Language dc:language: gre

Identifiers

dc:identifier.*

Identifier: 10.12681/eadd/0325
OAI identifier oai:identifier: oai:10442/0325