{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0325"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0325","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού","abstract":"TRYING TO ORGANIZE AS BETTER AS WE COULD OUR TISSUE TYPING LABORATORY WE STARTED ON COLLECTING SERA OF MULTIPOROUS WOMEN. SCREENING 306 SERA SAMPLES WE HAVEFOUND THAT 50 OF THOSE WOMEN (16.33%) WERE SENSITIZED AGAINST THEIR CHILDREN AND THAT PERCENTAGE SENSITIZATION INCREASES WITH INCREASING NUMBER OF PREGNANCIES. OUR TECHNIQUE WAS BASED PRIMARILY ON DIRECT AUTOTOXICITY OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE VERY LOW PERCENTAGE OF SENSITIZATION IN MOTHERS WITH B BLOOD GROUP. FURTHERMORE IT SEEMS THAT THERE IS A DIFFERENCE IN IMMUNOGENICITY BETWEEN HLA ANTIGENS IN FETO-MATERNAL RELATIONSHIP. SO HLA-B ANTIGENS ARE MORE FREQUENT IMMUNOGENIC AS COMPARED WITH ANTIGENS OF THE OTHER LOCI (A, DR, G). IN OUR SERIES HLA-BW22, B15 AND B27 WERE FOUND, AS JUDGED BY A RATIO OF IMMUNOGENICITY TO THE MOST POTENT ANTIGENS.","abstract_html":"TRYING TO ORGANIZE AS BETTER AS WE COULD OUR TISSUE TYPING LABORATORY WE STARTED ON COLLECTING SERA OF MULTIPOROUS WOMEN. SCREENING 306 SERA SAMPLES WE HAVEFOUND THAT 50 OF THOSE WOMEN (16.33%) WERE SENSITIZED AGAINST THEIR CHILDREN AND THAT PERCENTAGE SENSITIZATION INCREASES WITH INCREASING NUMBER OF PREGNANCIES. OUR TECHNIQUE WAS BASED PRIMARILY ON DIRECT AUTOTOXICITY OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE VERY LOW PERCENTAGE OF SENSITIZATION IN MOTHERS WITH B BLOOD GROUP. FURTHERMORE IT SEEMS THAT THERE IS A DIFFERENCE IN IMMUNOGENICITY BETWEEN HLA ANTIGENS IN FETO-MATERNAL RELATIONSHIP. SO HLA-B ANTIGENS ARE MORE FREQUENT IMMUNOGENIC AS COMPARED WITH ANTIGENS OF THE OTHER LOCI (A, DR, G). IN OUR SERIES HLA-BW22, B15 AND B27 WERE FOUND, AS JUDGED BY A RATIO OF IMMUNOGENICITY TO THE MOST POTENT ANTIGENS.","abstract_has_math":false,"creators":["Βλάσσης, Θεόδωρος"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1985,"date_issued":"1985","date_published":"1985","updated_at":"2026-07-24T02:25:11Z","subjects":["ΑΝΟΣΟΛΟΓΙΑ ΤΗΣ ΚΥΗΣΗΣ","ΕΜΒΡΥΟ-ΜΗΤΡΙΚΗ ΣΧΕΣΗ","ΚΥΤΤΑΡΟΤΟΞΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ΛΕΥΚΟΚΥΤΤΑΡΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ANTI-HLA ANTIGENS","CYTOTOXIC ANTIBODIES","FETO-MATERNAL RELATIONSHIP","IMMUNOLOGY OF THE PREGNANCY","LEUKOCYTE ANTIBODIES","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0325"],"render_values":[{"text":"10.12681/eadd/0325","href":"https://doi.org/10.12681/eadd/0325","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0325","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Βλάσσης, Θεόδωρος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1985"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΝΟΣΟΛΟΓΙΑ ΤΗΣ ΚΥΗΣΗΣ","ΕΜΒΡΥΟ-ΜΗΤΡΙΚΗ ΣΧΕΣΗ","ΚΥΤΤΑΡΟΤΟΞΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ΛΕΥΚΟΚΥΤΤΑΡΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ANTI-HLA ANTIGENS","CYTOTOXIC ANTIBODIES","FETO-MATERNAL RELATIONSHIP","IMMUNOLOGY OF THE PREGNANCY","LEUKOCYTE ANTIBODIES","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0325","http://hdl.handle.net/10442/hedi/0325"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["TRYING TO ORGANIZE AS BETTER AS WE COULD OUR TISSUE TYPING LABORATORY WE STARTED ON COLLECTING SERA OF MULTIPOROUS WOMEN. SCREENING 306 SERA SAMPLES WE HAVEFOUND THAT 50 OF THOSE WOMEN (16.33%) WERE SENSITIZED AGAINST THEIR CHILDREN AND THAT PERCENTAGE SENSITIZATION INCREASES WITH INCREASING NUMBER OF PREGNANCIES. OUR TECHNIQUE WAS BASED PRIMARILY ON DIRECT AUTOTOXICITY OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE VERY LOW PERCENTAGE OF SENSITIZATION IN MOTHERS WITH B BLOOD GROUP. FURTHERMORE IT SEEMS THAT THERE IS A DIFFERENCE IN IMMUNOGENICITY BETWEEN HLA ANTIGENS IN FETO-MATERNAL RELATIONSHIP. SO HLA-B ANTIGENS ARE MORE FREQUENT IMMUNOGENIC AS COMPARED WITH ANTIGENS OF THE OTHER LOCI (A, DR, G). IN OUR SERIES HLA-BW22, B15 AND B27 WERE FOUND, AS JUDGED BY A RATIO OF IMMUNOGENICITY TO THE MOST POTENT ANTIGENS.","ΣΤΗ ΠΡΟΣΠΑΘΕΙΑ ΜΑΣ ΝΑ ΟΡΓΑΝΩΘΕΙ ΚΑΛΥΤΕΡΑ ΤΟ ΚΕΝΤΡΟ ΜΑΣ ΣΤΟΝ ΤΟΜΕΑ ΤΗΣ ΙΣΤΙΚΗΣ ΣΥΜΒΑΤΟΤΗΤΑΣ ΑΡΧΙΣΑΜΕ ΣΥΛΛΟΓΗ ΟΡΩΝ ΑΠΟ ΠΟΛΥΤΟΚΕΣ ΓΥΝΑΙΚΕΣ. ΕΞΕΤΑΣΑΜΕ 306 ΔΕΙΓΜΑΤΑ ΚΑΙ ΒΡΗΚΑΜΕ ΟΤΙ ΟΙ 50 (16.33%) ΓΥΝΑΙΚΕΣ ΕΥΑΙΣΘΗΤΟΠΟΙΗΘΗΚΑΝ ΕΝΑΝΤΙ ΤΩΝ ΠΑΙΔΙΩΝ ΤΟΥΣ ΚΑΙ ΟΤΙ Η ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΑΥΞΑΝΕΙ ΜΕ ΤΟΝ ΑΡΙΘΜΟ ΤΩΝ ΤΟΚΕΤΩΝ. ΥΠΗΡΧΕ ΕΥΚΟΛΙΑ ΕΛΕΓΧΟΥ ΤΗΣ ΑΝΑΙΣΘΗΤΟΠΟΙΗΣΗΣ ΜΕ ΑΠΕΥΘΕΙΑΣ ΚΥΤΤΑΡΟΤΟΞΙΚΟΤΗΤΑ ΣΤΑ ΛΕΜΦΟΚΥΤΤΑΡΑ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ, ΑΛΛΑ ΚΑΙ ΔΥΣΚΟΛΙΑ ΤΥΠΟΠΟΙΗΣΗΣ ΓΙΑ ΤΑ HLA ΑΝΤΙΓΟΝΑ ΤΟΥ ΑΙΜΑΤΟΣ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ. ΣΗΜΑΝΤΙΚΟ ΕΥΡΗΜΑ ΗΤΑΝ Η ΜΙΚΡΗ ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΤΩΝ ΓΥΝΑΙΚΩΝ ΤΗΣ ΟΜΑΔΟΣ ΑΙΜΑΤΟΣ Β ΕΝΑΝΤΙ ΤΩΝ ΥΠΟΛΟΙΠΩΝ, ΚΑΘΩΣ ΚΑΙ Η ΔΙΑΦΟΡΑ ΑΝΤΙΓΟΝΙΚΟΤΗΤΑΣ ΤΩΝ HLA-ΑΝΤΙΓΟΝΩΝ ΣΤΗΝ ΕΜΒΡΥΟ-ΜΗΤΡΙΚΗ ΠΑΡΑΘΕΣΗ ΜΕ ΥΠΕΡΙΣΧΥΣΗ ΤΗΣ HLA-B ΓΟΝΙΔΙΑΚΗΣ ΘΕΣΗΣ ΕΝΑΝΤΙ ΤΩΝ ΑΛΛΩΝ ΚΑΙ ΑΠΟ ΠΛΕΥΡΑΣ ΑΝΤΙΓΟΝΙΚΟΤΗΤΑΣ ΤΩΝ BW22, B15, B27."]},{"key":"dc:title","label":"Title","values":["ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού","ANTI-HLA SENSITISATION OF MULTIPAPOUS WOMEN"]}]}],"canonical_facts":{"dc:creator":["Βλάσσης, Θεόδωρος"],"dc:date":["1985"],"dc:description":["TRYING TO ORGANIZE AS BETTER AS WE COULD OUR TISSUE TYPING LABORATORY WE STARTED ON COLLECTING SERA OF MULTIPOROUS WOMEN. SCREENING 306 SERA SAMPLES WE HAVEFOUND THAT 50 OF THOSE WOMEN (16.33%) WERE SENSITIZED AGAINST THEIR CHILDREN AND THAT PERCENTAGE SENSITIZATION INCREASES WITH INCREASING NUMBER OF PREGNANCIES. OUR TECHNIQUE WAS BASED PRIMARILY ON DIRECT AUTOTOXICITY OF MULTIPOROUS SERE AGAINST ONBILICOUS BLOOD LYMPHOCYTES. THIS WAS PROVED TO BE AN EASY REPRODUCIBLE SCREENING METHOD. ON THE CONTRARY HLA TYPING ON THE SAME LYMPHOCYTES WAS UNSUCCESFULL IN ALMOST 75% CONCERNING THE COMASKING OF PATERNAL ORIGIN HAPLOTYPE. ONE OF OUR MAJOR FINDING WAS THE VERY LOW PERCENTAGE OF SENSITIZATION IN MOTHERS WITH B BLOOD GROUP. FURTHERMORE IT SEEMS THAT THERE IS A DIFFERENCE IN IMMUNOGENICITY BETWEEN HLA ANTIGENS IN FETO-MATERNAL RELATIONSHIP. SO HLA-B ANTIGENS ARE MORE FREQUENT IMMUNOGENIC AS COMPARED WITH ANTIGENS OF THE OTHER LOCI (A, DR, G). IN OUR SERIES HLA-BW22, B15 AND B27 WERE FOUND, AS JUDGED BY A RATIO OF IMMUNOGENICITY TO THE MOST POTENT ANTIGENS.","ΣΤΗ ΠΡΟΣΠΑΘΕΙΑ ΜΑΣ ΝΑ ΟΡΓΑΝΩΘΕΙ ΚΑΛΥΤΕΡΑ ΤΟ ΚΕΝΤΡΟ ΜΑΣ ΣΤΟΝ ΤΟΜΕΑ ΤΗΣ ΙΣΤΙΚΗΣ ΣΥΜΒΑΤΟΤΗΤΑΣ ΑΡΧΙΣΑΜΕ ΣΥΛΛΟΓΗ ΟΡΩΝ ΑΠΟ ΠΟΛΥΤΟΚΕΣ ΓΥΝΑΙΚΕΣ. ΕΞΕΤΑΣΑΜΕ 306 ΔΕΙΓΜΑΤΑ ΚΑΙ ΒΡΗΚΑΜΕ ΟΤΙ ΟΙ 50 (16.33%) ΓΥΝΑΙΚΕΣ ΕΥΑΙΣΘΗΤΟΠΟΙΗΘΗΚΑΝ ΕΝΑΝΤΙ ΤΩΝ ΠΑΙΔΙΩΝ ΤΟΥΣ ΚΑΙ ΟΤΙ Η ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΑΥΞΑΝΕΙ ΜΕ ΤΟΝ ΑΡΙΘΜΟ ΤΩΝ ΤΟΚΕΤΩΝ. ΥΠΗΡΧΕ ΕΥΚΟΛΙΑ ΕΛΕΓΧΟΥ ΤΗΣ ΑΝΑΙΣΘΗΤΟΠΟΙΗΣΗΣ ΜΕ ΑΠΕΥΘΕΙΑΣ ΚΥΤΤΑΡΟΤΟΞΙΚΟΤΗΤΑ ΣΤΑ ΛΕΜΦΟΚΥΤΤΑΡΑ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ, ΑΛΛΑ ΚΑΙ ΔΥΣΚΟΛΙΑ ΤΥΠΟΠΟΙΗΣΗΣ ΓΙΑ ΤΑ HLA ΑΝΤΙΓΟΝΑ ΤΟΥ ΑΙΜΑΤΟΣ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ. ΣΗΜΑΝΤΙΚΟ ΕΥΡΗΜΑ ΗΤΑΝ Η ΜΙΚΡΗ ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΤΩΝ ΓΥΝΑΙΚΩΝ ΤΗΣ ΟΜΑΔΟΣ ΑΙΜΑΤΟΣ Β ΕΝΑΝΤΙ ΤΩΝ ΥΠΟΛΟΙΠΩΝ, ΚΑΘΩΣ ΚΑΙ Η ΔΙΑΦΟΡΑ ΑΝΤΙΓΟΝΙΚΟΤΗΤΑΣ ΤΩΝ HLA-ΑΝΤΙΓΟΝΩΝ ΣΤΗΝ ΕΜΒΡΥΟ-ΜΗΤΡΙΚΗ ΠΑΡΑΘΕΣΗ ΜΕ ΥΠΕΡΙΣΧΥΣΗ ΤΗΣ HLA-B ΓΟΝΙΔΙΑΚΗΣ ΘΕΣΗΣ ΕΝΑΝΤΙ ΤΩΝ ΑΛΛΩΝ ΚΑΙ ΑΠΟ ΠΛΕΥΡΑΣ ΑΝΤΙΓΟΝΙΚΟΤΗΤΑΣ ΤΩΝ BW22, B15, B27."],"dc:identifier":["10.12681/eadd/0325","http://hdl.handle.net/10442/hedi/0325"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["ΑΝΟΣΟΛΟΓΙΑ ΤΗΣ ΚΥΗΣΗΣ","ΕΜΒΡΥΟ-ΜΗΤΡΙΚΗ ΣΧΕΣΗ","ΚΥΤΤΑΡΟΤΟΞΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ΛΕΥΚΟΚΥΤΤΑΡΙΚΑ ΑΝΤΙΣΩΜΑΤΑ","ANTI-HLA ANTIGENS","CYTOTOXIC ANTIBODIES","FETO-MATERNAL RELATIONSHIP","IMMUNOLOGY OF THE PREGNANCY","LEUKOCYTE ANTIBODIES","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Health Sciences","Clinical Medicine"],"dc:title":["ΑΝΤΙ-HLA ΕΥΑΙΣΘΗΤΟΠΟΙΗΣΗ ΠΟΛΥΤΟΚΩΝ ΓΥΝΑΙΚΩΝ: αξιολόγηση των συχνοτέρων ευαισθητοποιούντων αντιγόνων στον ελληνικό πληθυσμό και της χρησιμότητάς τους στην μεταμόσχευση νεφρού","ANTI-HLA SENSITISATION OF MULTIPAPOUS WOMEN"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:11Z"}