Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΝΤΟΠΑΜΙΝΗΣ ΣΤΗΝ ΕΚΚΡΙΣΗ ΤΗΣ ΠΡΟΛΑΚΤΙΝΗΣ ΚΑΤΑ ΤΗ ΔΙΡΚΕΙΑ ΤΟΥ ΤΟΚΕΤΟΥ

THE PRESENT STUDY WAS DESIGNED TO INVESTIGATE THE ROLE OF DOPAMINE IN THE CONTROL OF PRL SECRETION DURING LABOR. FOURTEEN PREGNANT WOMEN WERE INCLUDED. ALL HAD DELIVERED VAGINALLY NORMAL BABIES. THE DURATION OF ACTIVE PHASE OF LABOR WAS 7 HOURS . VENOUS BLOOD SAMPLES WERE TAKEN FROM ALL THE WOMEN EVERY ONE HOURBEFORE AND DURING THE SEVEN HOURS POST-PARTUM. THE WOMEN WERE DIVIDED INTO THREE GROUPS: A) GROUP A: INCLUDED 5 WOMEN. NORMAL SALINE INFUSED INTRAVENOUSLY,B) GROUP B: INCLUDED 5 WOMEN. THEY WERE GIVEN AN INTRAVENOUS INFUSION OF METOCLOPRAMIDE AT A CONSTANT RATE (167 MG/MIN) C) GROUP C: INCLUDED 4 WOMEN. THEYRECEIVED 5 MGR OF ORAL BROMOCRIPTINE EVERY 4 HOURS. THE DURATION OF THE INFUSIONS IN GROUP A AND B WAS 14 HOURS (7 HOURS BEFORE THE DELIVERY AND 7 HOURS POSTPARTUM). IN ALL SAMPLES PRL WAS MEASURED BY A RADIOIMMUNOASSAY (NG/ML). STATISTICAL ANALYSIS OF THE RESULTS WAS PERFORMED BY STUDENT'S T-TEST AND ANALYSISOF VARIANCE. THE FOLLOWING WERE FOUND: SERUM PRL LEVELS STARTED TO DECLINE 5 HOURS BEFORE DELIVERY REACHING A NADIR 2 HOURS BEFORE DELIVERY IN BOTH GROUP A(343 +/- 57 NG/ML - 179 +/- 27 NG/ML, P < 0.05) AND GROUP B (481 +/- 59 NG/ML- 278 +/- 42 NG/ML, P < 0.05). THEREAFTER, PRL VALUES OF GROUP B WERE SIGNIFICANTLY HIGHER THAN OF GROUP A (P < 0.05). BUT THE PROFIL OF THE MULTIPHASIC SECRETION OF MATERNAL PRL WAS THE SAME IN BOTH GROUPS A AND B. IN GROUP C THE BROMOCRIPTINE DECREASED IN ALL WOMEN THE SERUM PRL LEVELS BUT THE MULTIPHASIC SECRETION WAS SAME AS IN GROUPS A AND B. IT IS CONCLUDED THAT IN NORMAL PREGNANT WOMEN PRL SECRETION DURING LABOR IS STILL UNDER THE INHIBITORY CONTROL BY DOPAMINE. THE RESULTS SHOW, FOR THE FIRST TIME THAT CENTRAL DOPAMINE DOES NOT SEEM TO REGULATE THE MULTIPHASIC SECRETION OF PRL DURING LABOR.

Grantor dc:publisher

University of Ioannina

Year dc:date

1986

Authors dc:creator

• Stefos, Theodoros
• Στέφος, Θεόδωρος

• ΑΝΑΣΤΟΛΕΑΣ ΕΚΚΡΙΣΗΣ ΠΡΟΛΑΚΤΙΝΗΣ
• Βρωμοκρυπτίνη
• ΕΝΔΟΚΡΙΝΟΛΟΓΙΑ ΤΗΣ ΓΥΝΑΙΚΑΣ
• ΜΕΤΟΚΛΟΠΡΑΜΙΔΗ
• Ντοπαμίνη
• Προλακτίνη
• Φυσιολογικός τοκετός
• Bromocriptine
• Delivery
• Dopamine
• METOCLOPRAMIDE
• Prolactin
• PROLACTIN INHIBITING FACTOR
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0103

OAI identifier oai:identifier

oai:10442/0103