ΣΥΝΘΕΣΗ ΚΑΙ ΦΑΡΜΑΚΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΜΕΡΙΚΩΝ ΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ ΜΟΡΦΟΛΙΝΩΝ ΜΕ ΒΙΟΛΟΓΙΚΟ ΕΝΔΙΑΦΕΡΟΝ

A NUMBER OF NEW MORPHOLINE DERIVATIVES ARE SYNTHESIZED AND THE IMPORTANCE OF VARIOUS EFFECTS (E.G. INDUCTIVE, MESOMERIC, STEREOCHEMICAL) IS STUDIED. IONIZATION CONSTANTS (PKA'S) AND PARTITION COEFFICIENTS (N-OCTANOL-WATER OF THE SYNTHESIZED MORPHOLINES ARE DETERMINED EXPERIMENTALLY. THE RESULTS ARE DISCUSSED IN TERMS OF CONFORMATIONAL, INDUCTIVE AND STERIC EFFECTS. THE VALUES OF THE TWO ABOVEMENTIONED PHYSICOCHEMICAL PARAMETERS ARE PREDICTED USING THE APPROPRIATE TAFT EQUATION AND REKKER'S HYDROPHOBIC FRAGMENTAL CONSTANT SYSTEM, COMPARED TO THOSEEXPERIMENTALLY FOUND AND THE RELIABILITY OF THE PREDICTIVE METHODS IS DISCUSSED. THE LETHAL DOSES (RATS) OF THE MORPHOLINE DERIVATIVES ARE FOUND. THE ANALGESI C ACTIVITY (HOT PLATE) AS WELL AS THE HYPERKINESIA AND STEREOTYPED BEHAVIOUR CAUSED BY THE MORPHOLINE DERIVATIVES IN RATS ARE DETERMINED. AN ATTEMPT IS MADETO CORRELATE STRUCTURE, PHYSICOCHEMICAL PROPERTIES/BIOLOGIC ACTIVITY.

Grantor dc:publisher

Aristotle University Of Thessaloniki (AUTH)

Year dc:date

1986

Authors dc:creator

• Ρέκκα, Ελένη
• Rekka, Eleni

• Αναλγησία
• ΚΕΝΤΡΙΚΗ ΣΥΜΠΑΘΟΜΙΜΗΤΙΚΗ ΔΡΑΣΗ
• ΜΟΡΦΟΛΙΝΕΣ
• Προβλέψεις
• ΣΤΑΘΕΡΑ ΙΟΝΙΣΜΟΥ
• Σύνθεση
• Συντελεστής κατανομής
• Analgesia
• CENTRAL SYMPATHOMIMETIC ACTIVITY
• IONIZATION CONSTANT
• MORPHOLINES
• PARTION COEFFICIENT
• PREDICTIONS
• Synthesis
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0010

OAI identifier oai:identifier

oai:10442/0010