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Showing 1 to 8 of 8 for “"MORPHOLINES"”.
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Flexible access to an array of optically-enriched conformationally-locked bicyclic morpholines and approaching bridged bicyclic piperazines
… in exploring the bioactivity of bridged morpholines, as well as bridged piperazines. Despite the interest in these types of compounds, there is a lack of routes into these scaffolds which allow for diversification surrounding the core scaffold. Consequently, the focus of this study was to …
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Developments in Acyl-Claisen Rearrangements and Application to Synthesis
… asymmetric variant. Preparation of 3-substituted morpholines 181a-g from amino alcohols was carried out and subsequent allylation of these morpholines provided chiral substrates for the acyl-Claisen rearrangement. Rearrangement of many of these chiral allylic morpholines 182a-h/183a-h proved …
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1. Reinvestigation of a catalytic, enantioselective alkene dibromination and chlorohydroxylation, 2. Double cross-coupling reactions of siloxaborolates, 3. The enantioselective synthesis of 3-substituted morpholines using computer-guided catalyst design
… the enantioselective synthesis of C-substituted morpholines, for which a general and highly-selective cyclization has not yet been discovered. A number of ligands were tested for the cyclization of SnAP imines to this purpose, this being a highly general method for morpholine synthesis that …
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DESIGN AND SYNTHESIS OF ALPHA-AMINO ACID AND MORPHOLINO `CHIMERA' BUILDING-BLOCKS
… we improved a synthesis of 2,6-disubstituted morpholines by the double and consecutive oxirane ring-opening under SL-PTC, followed by regioselective conversion of only one hydroxy group into a leaving group. Our background in the synthesis of 2,6-disobstituted morpholines, made us focus our …
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ΣΥΝΘΕΣΗ ΚΑΙ ΦΑΡΜΑΚΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΜΕΡΙΚΩΝ ΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ ΜΟΡΦΟΛΙΝΩΝ ΜΕ ΒΙΟΛΟΓΙΚΟ ΕΝΔΙΑΦΕΡΟΝ
… COEFFICIENTS (N-OCTANOL-WATER OF THE SYNTHESIZED MORPHOLINES ARE DETERMINED EXPERIMENTALLY. THE RESULTS ARE DISCUSSED IN TERMS OF CONFORMATIONAL, INDUCTIVE AND STERIC EFFECTS. THE VALUES OF THE TWO ABOVEMENTIONED PHYSICOCHEMICAL PARAMETERS ARE PREDICTED USING THE APPROPRIATE TAFT EQUATION AND …
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A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
… piperidines, azepanes, azamacrocycles, morpholines, and thiomorpholines are common structural motifs found in a wide range of pharmaceuticals such as carmegliptine, levofloxacin, thioridazine, claviciptic acid, and azithomycin. As a result, there is a strong desire to construct highly …
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Synthesis, Vinylation and Rearrangement of NH-Isoxazolines and Copper Catalyzed 6 Pi Electrocyclization
… copper catalyzed 6 π electrocyclization to form morpholines and morpholine–N–oxides via an initial Chan–Lam coupling followed by spontaneous electrocyclization.
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Synthesis of Lignans Utilising the Acyl-Claisen Rearrangement: Total Syntheses of (+)-Ovafolinin A, B, (–)-Bicubebin A, B and (+)-Bicubebin C
… propionyl chlorides and 4-phenylbut-2-en-1-yl morpholines to give 2,3- dibenzyl morpholine pentenamides. Upon dihydroxylation, these compounds cyclise to give 5- hydroxymethyl analogues of dibenzyl butyrolactone lignans. Reduction of these compounds followed by oxidative cleavage and subsequent …