Regulation of Galactosylceramide Biosynthesis

An important branchpoint of mammalian sphingolipid metabolism occurs at the step where ceramides are glycosylated to glucosylceramide (GlcCer) versus galactosylceramide (GalCer), which are precursors of all mammalian glycosphingolipids. Relatively few studies have focused on this branchpoint because these monohexosylceramides are somewhat difficult to resolve chromatographically and because molecular biology tools have only recently become available to follow expression of these genes. The goal of this thesis is to better understand the mechanisms of cell regulation determining galactosylceramide synthesis.

Department dc:contributor.department

Biology

Grantor dc:publisher

Georgia Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Kollmeyer, Jessica Elaine

Advisor dc:contributor.advisor

• Merrill, Alfred H.

Committee members dc:contributor.committeemember

• M. Cameron Sullards
• Sewer, Marion B.

• Galacotsylceramide
• Glycosphingolipids
• Sphingolipids

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1853/11630

OAI identifier oai:identifier

oai:repository.gatech.edu:1853/11630