Effect of Gender on the Association of Single-Nucleotide Polymorphisms with Bipolar Disorder

<p>Bipolar disorder is a relatively common form of mental illness that depends strongly on genetic inheritance for expression. The author of this study has sought to evaluate whether the gender of subjects influences which genetic variants are associated with the disease. A portion of the cases from a previously published study were analyzed using PLINK software and the association of single-nucleotide polymorphisms was evaluated separately for all cases, for female subjects alone, and for male subjects alone. The results obtained for male subjects alone reached higher levels of statistical significance than when both genders were evaluated together or when female subjects were evaluated alone. The most significantly scoring polymorphisms were distinctly different for the 2 genders. In particular, a site downstream of the ion exchanger SLC24A3 and upstream of the Rab5-interacting protein RIN2 gene on chromosome 20 (rs6046396) yielded very high significance in men (p=3.91 X 10-9).</p>

Name thesis:degree_name

MPH (Master of Public Health)

Level thesis:degree_level

Thesis - unrestricted

Discipline thesis:degree_discipline

Public Health

Year dc:date.issued

2011

Author dc:creator

• Mullersman, Jerald Eric

• genome-wide association
• bipolar disorder
• single nucleotide polymorphisms
• gender
• Public Health

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/1230

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-2416