Antinociceptive actions of descending catecholaminergic tracts on dorsal horn somatosensory neurones

Ionophoretically-applied dopamine and noradrenaline selectively inhibited the nociceptive responses of multireceptive somatosensory dorsal horn neurones, whilst non-nociceptive responses, spontaneous activity and activity evoked by an ionophoretically-applied excitatory amino acid, DL-homocysteic acid were unaffected. Many of the neurones tested had long ascending projections, capable of transmitting nociceptive information to supraspinal sites; in the rat (spinothalamic tract neurones) and in the cat (spinocervical tract neurones).

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

1986

Author dc:creator

• Hope, Philippa J.

Handle dc:identifier.uri

http://hdl.handle.net/1842/29803

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/29803