Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"spontaneous activity"”.
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Spontaneous activity in the mouse visual cortical slice: biophysical characterization and pathophysiology
… visual cortical slices exhibit increased spiking activity in layer 5. Critically, this hyperactivity phenotype is rapidly reversed not only by treatments known to restore elevated rates of protein synthesis to WT levels, but also by the protein synthesis inhibitor cycloheximide. Therefore, rapidly …
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Trpv1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity In Nociceptors After Spinal Cord Injury
… contusive SCI results in a large increase in spontaneous activity in primary nociceptors, which is correlated significantly with mechanical allodynia and thermal hyperalgesia. Upregulation of ion channel transient receptor vanilloid 1 (TRPV1) has been observed in the dorsal horn of the spinal …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… tests. In the first experiment, locomotor activity in a familiar environment was measured after mice received an injection of the DREADD ligand CNO (1 or 2.5 mg/kg) or vehicle. Both lines of mice exhibited decreases in spontaneous activity in response to the high dose of CNO. Second, …
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Investigations of neuronal network responses to electrical stimulation in murine spinal cultures.
Spontaneous activity in neuronal networks in vitro is common and has been well documented. However, alteration of spontaneous activity in such networks via conditioning electrical stimulation has received much less experimental attention. Two different patterns of electrical stimulation were used …
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Antinociceptive actions of descending catecholaminergic tracts on dorsal horn somatosensory neurones
… horn neurones, whilst non-nociceptive responses, spontaneous activity and activity evoked by an ionophoretically-applied excitatory amino acid, DL-homocysteic acid were unaffected. Many of the neurones tested had long ascending projections, capable of transmitting nociceptive information to …
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Time-varying phase relationship between spiking neuronal responses and local field potentials in olfactory processing in manduca sexta
… illustrated that phase locking was higher during spontaneous activity than during odor response. Finally, in disagreement with TOM predictions, disruption of GABA A receptors by BMI application reduced odor-driven LFP oscillations across time-periods and regions of the AL. Further BMI application …
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Towards a better speech processor for cochlear implants : auditory- nerve responses to high-rate electric pulse trains
… ongoing, stochastic discharges similar to the spontaneous activity in a healthy hear. We tested this hypothesis by recording responses of ANfibers of deafened cats to sustained electric pulse trains. For most fibers, responses to the DPT showed adaptation during the first 2 minutes, followed by …
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Genetic Mechanisms Responsible for Dietary Restriction Dependent Lifespan Extension in Drosophila Melanogaster: A Role for Muscle Tissue
… that is known to extend lifespan and increase spontaneous activity in multiple species. Whether activity increase plays a causal role in mediating the health protective benefits of DR remains unknown. To investigate this relationship, nutritional manipulations and laboratory selection for …
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Modificazioni neuronali nella via abenulo-mesencefalica durante l’astinenza da Δ9-tetraidrocannabinolo
… tegmental area (VTA), shows a reduction in its spontaneous activity after chronic cannabinoid exposure and withdrawal, the critical phases of the drug addiction cycle. These adaptive changes, which result from imbalances between excitatory and inhibitory afferents onto DA cells, are thought to …
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Form in Darkness: Linking Visual Cortex Structure With Spontaneous Neural Function
Spontaneous neural activity within visual cortex is synchronized at varying spatial scales, from the cytoarchitecural level of individual neurons to the coarse scale of whole regions. The neural basis of this synchronicity remains ambiguous. In this thesis, we focus on the role visual experience …
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Studies on the stimulant action of human gamma-globulin on spontaneous contractility: interaction with K⁺-channel openers and postaglandin inhibitors
… action of human gamma-globulin on the spontaneous activity of the rat mesenteric portal vein. Previous studies in our laboratory have identified human gamma-globulin and IgG as stimulatory factors which may be responsible for the smooth muscle abnormality associated with the etiology of …
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Metal Oxide Semiconductors for Solar Energy Harvesting
… using metal-oxide semiconductors: visible light activity and spontaneous activity. To address the light absorption issue, a combined theory-experiment approach was taken to understand the fundamental role of chemical composition in determining the visible light absorption properties of mixed …
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… integrated microelectrode arrays (MEAs) generate spontaneous activity that can be recorded for up to several weeks. The signature wave shapes from extracellular recording of neuronal activity display a great variety of shapes with triphasic signals predominating. I characterized extracellular …
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근전도 검사상 비정상 자발전위를 보이는 요통 환자에서 척추주위근의 자기공명영상학적 분석
… Patients were grouped into those with abnormal spontaneous activities in paraspinal muscle and those who are normal. Muscle and fat areas were measured via MR sagittal image at L4-5 level after processed by pseudo coloring technique and their ratios were compared statistically. RESULTS: Although …
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Approaches to Understanding the Function of Intrinsic Activity and its Relationship to Task-evoked Activity in the Human Brain
… activation-based paradigm treated underlying spontaneous brain activity, a.k.a. intrinsic activity, as noise hence irrelevant to cognitive or behavioral functions. This view, however, has been profoundly modified by the discovery that intrinsic activity is not random, but temporally correlated …
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Neural Dynamics in the Developing Piriform Cortex of Awake Rats
… For example, before maturation of the retina, spontaneous retinal waves trigger 10 Hz spindle oscillations in the thalamocortical loop that drive plastic changes in visual cortex. Little is known about the development of piriform olfactory cortex—a three-layer paleocortex that lacks thalamic …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
… medium. Continual multi-channel recording of spontaneous action potential generation allowed a quantitative analysis of the temporal evolution of network spike activity generation at specific zinc acetate concentrations. Cultures responded with immediate concentration-dependent excitation …
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Engineering Principles to Design and Analyze Patterned Neuronal Cultures Using Multielectrode Arrays
… were used to record evoked responses as well as spontaneous activity of patterned cultures in vitro. These cultures showed synchronized bursting activity after 2 weeks and time-locked responses in respond to electrical stimulations. Different electrode configurations were tested to study the …
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Age-associated changes to calcium handling proteins across the whole heart
… cycling was established as crucial for pacemaker activity. Application of cylopiazonic acid profoundly reduced the response to isoprenaline in the younger age groups but had no effect in the elderly, elucidating the age-associated reduced role of SERCA2a. The decline in protein expression of …
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Impact of Brain State On Visual and Prefrontal Population Coding In Behaving Animals
<p>Patterns of neural activity in the brain constantly shift between different processing states. Earlier studies have established that the ongoing, spontaneous activity has major repercussions regarding how the brain processes incoming sensory stimuli. However, the interaction between behavioral …
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