Characterisation of the role of Sox4 in mouse embryonic development

The molecular complexity of cardiogenesis is revealed by the high incidence of heart phenotypes resulting from mutation to any of a vast number of genes across multiple pathways. Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in aspects of heart development. A developmental role for Sox4 has been shown in mouse cardiogenesis, as apparent by the phenotype of two published alleles. Both null and conditional null mutant alleles exhibit septation defects, oedema, and lethality by E14.5. However, the causative step in development, where a loss of functional Sox4 marks the beginning of the defect, has not been described; nor has it been uncovered whether mutation to Sox4 results in dysregulation of other aspects of embryonic patterning.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

2010

Author dc:creator

• Mulford, Christine-Margaret

Handle dc:identifier.uri

http://hdl.handle.net/1842/29284

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/29284