Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 465 for “"embryonic development"”.
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CBD & Ethanol Disrupt Early Embryonic Development
… Zebrafish, a viable translational model for embryonic and neural development, is a cost-effective and translational model that has previously been used in drug research. In the present study, zebrafish embryos were chronically exposed to CBD for 10 days. Embryonic development was assessed at …
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Mesoderm diversification during mouse embryonic development
During early mouse embryonic development, a single cell, the fertilised egg, will give rise to a wide range of cell types that become specialised at a functional and molecular level. Gastrulation and early organogenesis are two of the most critical events during these early stages, when pluripotent …
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Liver Cell Adhesion Molecules in Embryonic Development
<p>Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos …
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Mitochondrial DNA replication in pre-implantation embryonic development
… in oocytes, pre-implantation embryos and embryonic stem cells (ESCs) and that this may be disrupted following nuclear transfer (NT). MtDNA copy number decreased between 2-cell and 8-cell staged porcine embryos and increased between the morula and expanded blastocyst stages, coinciding with …
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Factors Influencing Early Embryonic Development in the Pig
… 30 nM, 100 nM, 300 nM, 1 muM and 3 muM) had no developmental effect on pig embryos, however pig embryos cultured with 3 muM daidzein may improve blastocyst formation over control embryos. Further studies will be required to determine whether higher levels of these phytoestrogens affect embryonic …
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Programming of the paternal nucleus for embryonic development
… However, it is known that sperm supports embryonic development better than other cell types, suggesting that it might also have additional important, non-genetic contributions to embryonic development. The work described in this dissertation focuses on identifying the molecular …
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Manipulating Embryonic Development and Endometrial Function in Ruminants
… is highlighted by the emergence of several embryonic end extraembryonic lineages. One such lineage is the primitive endoderm, which will eventually give rise to the yolk sac. Once believed to be a vestigial structure, the yolk sac is now believed to play a more prominent role in …
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… blastopore and “open-back” defect during embryonic development. Interestingly, overexpression of Dennd5a by microinjection of RNA leads to very similar phenotype.
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New Tools for Real-Time Study of Embryonic Development
<p>Embryonic development represents one of the most complex and dynamic cellular processes in biology, and plays vital roles in understanding of functions of embryonic stem cells (ESCs) and design of ESC-based therapy. Conventional assays and fluorescence-based imaging methods have been widely used …
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Digit formation during embryonic development of bats and mice
… HL, has seen extensive research into bat wing development in an effort to determine the molecular mechanism driving limb development. A recent RNA-seq and ChIP-seq study carried out on M. natalensis showed differences in FL and HL activity for several genetic pathways known to be involved in …
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Dissecting Pluripotency and Mammalian Embryonic Development via Droplet Microfluidics
… pluripotency can be captured in the form of embryonic stem cells (ESCs). In this study, I developed a microfluidic-based system to encapsulate ESCs into agarose microgels, three-dimensional scaffolds that are in terms of their mechanical and biochemical properties fundamentally different from …
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The role of imprinting in embryonic development and tumorigenesis
… with this, many imprinted genes are involved in embryonic or placental growth by regulating mitogenic pathways or the cell cycle. Loss of imprinting (LOI) has been found at specific loci in cancers, raising the possibility that altered expression of imprinted genes may also contribute to …
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Characterisation of the role of Sox4 in mouse embryonic development
… Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in aspects of heart development. A developmental role for Sox4 has been shown in mouse cardiogenesis, as apparent by the phenotype of two published alleles. Both null and conditional …
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Probing early human embryonic development to characterize BMP signaling stimulators
Bone morphogenetic proteins (BMPs) sind sowohl in der Embryonalentwicklung als auch im adulten Organismus von entscheidender Bedeutung. Da ein fehlregulierter Signalweg mit zahlreichen chronischen und schwerwiegenden Krankheiten assoziiert ist, stellt dessen Modulierung einen vielversprechenden …
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IMPORTANCE OF SLOW EMBRYONIC DEVELOPMENT IN OFFSPRING AND ADULT IMMUNE FUNCTION
Why species differ in rate of development and quality of offspring is a central question in life history theory. A physiological trade-off is thought to occur between the rate of development and enhancement of internal systems, such as immune function, which determine high offspring quality. For …
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IMPORTANCE OF SLOW EMBRYONIC DEVELOPMENT IN OFFSPRING AND ADULT IMMUNE FUNCTION
Why species differ in rate of development and quality of offspring is a central question in life history theory. A physiological trade-off is thought to occur between the rate of development and enhancement of internal systems, such as immune function, which determine high offspring quality. For …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… organisms to gain insight into human health and development. Traditionally, the mouse has been the favoured vertebrate model, due to its experimental and genetic tractability. Non-rodent embryological studies however highlight that many aspects of early mouse development, including the …
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The role of Dichaete in transcriptional regulation during Drosophila embryonic development
Sox domain genes encode a family of developmentally important transcription factors conserved throughout the Metazoa. The subgroup B, which includes the mammalian Sox1, 2 and 3 proteins and their Drosophila counterparts Dichaete and SoxNeuro, are particularly important for the development of the …
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