ER to Golgi transport during apoptosis

The Golgi complex, a single -copy organelle, is composed of a ribbon of flattened stacks of cisternae during interphase. However, during apoptosis the Golgi is shown to fragment and disperse throughout the cytoplasm. Immunoelectron microscopy identified these fragments as vesicular-tubular structures that contained the Golgi marker n-acetyl-glucosaminyl-transferase-1. Newly-synthesised proteins translocated to the endoplasmic reticulum also failed to exit from this organelle and reach the Golgi in apoptotic cells.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

2002

Author dc:creator

• Walker, Annemieke

Handle dc:identifier.uri

http://hdl.handle.net/1842/27589

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/27589