University of East Anglia
Application of asymmetric C-‐H activation to the synthesis of Planar Chiral Catalysts and Ligands.
Abstract
dc:description.abstractThe synthesis and application of ferrocene-‐based palladacycles has been at the forefront of catalysis for a number of years. The use of C-‐H activation to synthesise such compounds has been a relatively new development. The work within this thesis attempts to develop on known protocols devised by Richards et al. for the generation of enantioenriched planar chiral palladacycles.1. The first of which includes the synthesis and application of symmetrical and non-‐symmetrical phosphines, and in this work the latter have been transformed into a diastereomerically pure enantiomerically enriched palladacycle via a transcyclopalladation (Scheme I). Compound 343 was generated as a diastereomerically pure palladacycle in 96% ee, and the kinetic resolution of the phosphine pre-‐courser to 319 afforded a d.r. of 99:1 and a 76% ee. Finally, methods developed by Shu Li-‐You and Wu have been extended to a cobalt sandwich complex affording novel bi-‐substituted ligands (Scheme II).2
Degree
thesis:*- Name dc:type.qualificationname
- phd
- Level dc:type.qualificationlevel
- doctoral
- Grantor dc:publisher.institution
- University of East Anglia
- Year dc:date.issued
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Panchal, Ketan
Rights
- Language dc:language
- en