{"id":{"repo_id":"east-anglia","oai_identifier":"oai:ueaeprints.uea.ac.uk:53358"},"canonical_url":"https://search.dev.ndltd.org/etd/east-anglia/oai:ueaeprints.uea.ac.uk:53358","repository":{"repo_id":"east-anglia","name":"University of East Anglia","base_url":"https://ueaeprints.uea.ac.uk/cgi/oai2"},"display":{"title":"Application of asymmetric C-­‐H activation to the synthesis of Planar Chiral Catalysts and Ligands.","abstract":"The synthesis and application of ferrocene-­‐based palladacycles has been at the forefront of catalysis for a number of years. The use of C-­‐H activation to synthesise such compounds has been a relatively new development. The work within this thesis attempts to develop on known protocols devised by Richards et al. for the generation of enantioenriched planar chiral palladacycles.1. The first of which includes the synthesis and application of symmetrical and non-­‐symmetrical phosphines, and in this work the latter have been transformed into a diastereomerically pure enantiomerically enriched palladacycle via a transcyclopalladation (Scheme I). Compound 343 was generated as a diastereomerically pure palladacycle in 96% ee, and the kinetic resolution of the phosphine pre-­‐courser to 319 afforded a d.r. of 99:1 and a 76% ee. Finally, methods developed by Shu Li-­‐You and Wu have been extended to a cobalt sandwich complex affording novel bi-­‐substituted ligands (Scheme II).2","abstract_html":"The synthesis and application of ferrocene-­‐based palladacycles has been at the forefront of catalysis for a number of years. The use of C-­‐H activation to synthesise such compounds has been a relatively new development. The work within this thesis attempts to develop on known protocols devised by Richards et al. for the generation of enantioenriched planar chiral palladacycles.1. The first of which includes the synthesis and application of symmetrical and non-­‐symmetrical phosphines, and in this work the latter have been transformed into a diastereomerically pure enantiomerically enriched palladacycle via a transcyclopalladation (Scheme I). Compound 343 was generated as a diastereomerically pure palladacycle in 96% ee, and the kinetic resolution of the phosphine pre-­‐courser to 319 afforded a d.r. of 99:1 and a 76% ee. Finally, methods developed by Shu Li-­‐You and Wu have been extended to a cobalt sandwich complex affording novel bi-­‐substituted ligands (Scheme II).2","abstract_has_math":false,"creators":["Panchal, Ketan"],"institution":"University of East Anglia","degree_name":"phd","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-09","date_published":"2014-09","updated_at":"2026-07-24T02:12:08Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Panchal, Ketan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-09"]},{"key":"dc:date.issued","label":"Date","values":["2014-09"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of East Anglia"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://ueaeprints.uea.ac.uk/id/eprint/53358/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["phd"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://ueaeprints.uea.ac.uk/id/eprint/53358/1/2014PanchalKMPhD.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The synthesis and application of ferrocene-­‐based palladacycles has been at the forefront of catalysis for a number of years. The use of C-­‐H activation to synthesise such compounds has been a relatively new development. The work within this thesis attempts to develop on known protocols devised by Richards et al. for the generation of enantioenriched planar chiral palladacycles.1. The first of which includes the synthesis and application of symmetrical and non-­‐symmetrical phosphines, and in this work the latter have been transformed into a diastereomerically pure enantiomerically enriched palladacycle via a transcyclopalladation (Scheme I). Compound 343 was generated as a diastereomerically pure palladacycle in 96% ee, and the kinetic resolution of the phosphine pre-­‐courser to 319 afforded a d.r. of 99:1 and a 76% ee. Finally, methods developed by Shu Li-­‐You and Wu have been extended to a cobalt sandwich complex affording novel bi-­‐substituted ligands (Scheme II).2"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Application of asymmetric C-­‐H activation to the synthesis of Planar Chiral Catalysts and Ligands."]}]}],"canonical_facts":{"dc:creator":["Panchal, Ketan"],"dc:date":["2014-09"],"dc:date.issued":["2014-09"],"dc:description.abstract":["The synthesis and application of ferrocene-­‐based palladacycles has been at the forefront of catalysis for a number of years. The use of C-­‐H activation to synthesise such compounds has been a relatively new development. The work within this thesis attempts to develop on known protocols devised by Richards et al. for the generation of enantioenriched planar chiral palladacycles.1. The first of which includes the synthesis and application of symmetrical and non-­‐symmetrical phosphines, and in this work the latter have been transformed into a diastereomerically pure enantiomerically enriched palladacycle via a transcyclopalladation (Scheme I). Compound 343 was generated as a diastereomerically pure palladacycle in 96% ee, and the kinetic resolution of the phosphine pre-­‐courser to 319 afforded a d.r. of 99:1 and a 76% ee. Finally, methods developed by Shu Li-­‐You and Wu have been extended to a cobalt sandwich complex affording novel bi-­‐substituted ligands (Scheme II).2"],"dc:format":["application/pdf"],"dc:identifier.uri":["https://ueaeprints.uea.ac.uk/id/eprint/53358/1/2014PanchalKMPhD.pdf"],"dc:language":["en"],"dc:publisher.department":["School of Chemistry"],"dc:publisher.institution":["University of East Anglia"],"dc:relation.isreferencedby":["https://ueaeprints.uea.ac.uk/id/eprint/53358/"],"dc:title":["Application of asymmetric C-­‐H activation to the synthesis of Planar Chiral Catalysts and Ligands."],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["phd"]},"updated_at":"2026-07-24T02:12:08Z"}