Studies Towards a Total a Synthesis of Tagetitoxin

Tagetitoxin is a phytotoxin produced by the bacterium Pseudomonas syringae pv. tagetis. It is a selective inhibitor of RNA polymerase III in eukaryotic cells and RNA polymerase in bacteria. Since its initial isolation and partial characterization, more than thirty years have passed without a fully characterized structure for tagetitoxin. While much research has been carried out on the biological aspects of tagetitoxin, particularly with interests towards its activity as an inhibitor of RNA polymerase, very few published works are available from a synthetic perspective. Figure 1: Synthetic intermediates towards tagetitoxin In this thesis several promising synthetic intermediates towards the goal of tagetitoxin were synthesized (Figure 1). Herein the previous work related to the biology and synthetic studies of tagetitoxin and the recent studies conducted in the group towards a total synthesis of the molecule is described.

Name dc:type.qualificationname

phd

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

University of East Anglia

Year dc:date.issued

2013

Author dc:creator

• Pearce, Christopher

Language dc:language

en