Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters

Thyroid hormones (TH) exert their multitude of effects on body development,<br/>growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,<br/>therefore extracellular TH must first cross the plasma membrane to gain entry<br/>into the cell. The exact mechanisms of TH transport across the plasma<br/>membrane are only beginning to be clarified, but it is likely that transport may<br/>be an important control step for the effects of TH on transcription. Members of<br/>the recently cloned organic anion transporting polypeptide (OATP) family have<br/>been shown to transport TH. Inhibitor studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various cell types.<br/>However cloned amino acid transporters have not been studied to demonstrate<br/>directly whether they can accept TH as substrates.<br/><br/>

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

University of Dundee

Year dc:date.issued

2000

Author dc:creator

• Ritchie, James William Alexander

• Thyroid hormones
• Amino acids
• membrane transport
• uptake kinetics

Language dc:language

eng

Identifier

oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050

OAI identifier oai:identifier

oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050