{"id":{"repo_id":"dundee","oai_identifier":"oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050"},"canonical_url":"https://search.dev.ndltd.org/etd/dundee/oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050","repository":{"repo_id":"dundee","name":"University of Dundee","base_url":"https://discovery.dundee.ac.uk/ws/oai"},"display":{"title":"Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters","abstract":"Thyroid hormones (TH) exert their multitude of effects on body development,<br/>growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,<br/>therefore extracellular TH must first cross the plasma membrane to gain entry<br/>into the cell. The exact mechanisms of TH transport across the plasma<br/>membrane are only beginning to be clarified, but it is likely that transport may<br/>be an important control step for the effects of TH on transcription. Members of<br/>the recently cloned organic anion transporting polypeptide (OATP) family have<br/>been shown to transport TH. Inhibitor studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various cell types.<br/>However cloned amino acid transporters have not been studied to demonstrate<br/>directly whether they can accept TH as substrates.<br/><br/>","abstract_html":"Thyroid hormones (TH) exert their multitude of effects on body development,&lt;br/&gt;growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,&lt;br/&gt;therefore extracellular TH must first cross the plasma membrane to gain entry&lt;br/&gt;into the cell. The exact mechanisms of TH transport across the plasma&lt;br/&gt;membrane are only beginning to be clarified, but it is likely that transport may&lt;br/&gt;be an important control step for the effects of TH on transcription. Members of&lt;br/&gt;the recently cloned organic anion transporting polypeptide (OATP) family have&lt;br/&gt;been shown to transport TH. Inhibitor studies indicate that both the aromatic&lt;br/&gt;amino acid System T-type transporter, and the broad scope neutral amino acid&lt;br/&gt;transporter System L are mediators of TH uptake into various cell types.&lt;br/&gt;However cloned amino acid transporters have not been studied to demonstrate&lt;br/&gt;directly whether they can accept TH as substrates.&lt;br/&gt;&lt;br/&gt;","abstract_has_math":false,"creators":["Ritchie, James William Alexander"],"institution":"University of Dundee","degree_name":"Doctor of Philosophy","degree_level":"Doctoral Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2000,"date_issued":"2000","date_published":"2000","updated_at":"2026-07-24T02:08:19Z","subjects":["Thyroid hormones","Amino acids","membrane transport","uptake kinetics"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050"],"render_values":[{"text":"oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050","href":null,"code":true}]}]},"links":{"outbound_url":"https://discovery.dundee.ac.uk/en/studentTheses/4a30ffbf-102f-484f-be68-61d133333050","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["Biotechnology and Biological Sciences Research Council"]},{"key":"dc:creator","label":"Author","values":["Ritchie, James William Alexander"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2000"]},{"key":"dc:date.issued","label":"Date","values":["2000"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Dundee"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://discovery.dundee.ac.uk/en/studentTheses/4a30ffbf-102f-484f-be68-61d133333050"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Thyroid hormones","Amino acids","membrane transport","uptake kinetics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050","https://discovery.dundee.ac.uk/en/studentTheses/4a30ffbf-102f-484f-be68-61d133333050"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Thyroid hormones (TH) exert their multitude of effects on body development,<br/>growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,<br/>therefore extracellular TH must first cross the plasma membrane to gain entry<br/>into the cell. The exact mechanisms of TH transport across the plasma<br/>membrane are only beginning to be clarified, but it is likely that transport may<br/>be an important control step for the effects of TH on transcription. Members of<br/>the recently cloned organic anion transporting polypeptide (OATP) family have<br/>been shown to transport TH. Inhibitor studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various cell types.<br/>However cloned amino acid transporters have not been studied to demonstrate<br/>directly whether they can accept TH as substrates.<br/><br/>"]},{"key":"dc:title","label":"Title","values":["Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters"]}]}],"canonical_facts":{"dc:contributor.sponsor":["Biotechnology and Biological Sciences Research Council"],"dc:creator":["Ritchie, James William Alexander"],"dc:date":["2000"],"dc:date.issued":["2000"],"dc:description.abstract":["Thyroid hormones (TH) exert their multitude of effects on body development,<br/>growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,<br/>therefore extracellular TH must first cross the plasma membrane to gain entry<br/>into the cell. The exact mechanisms of TH transport across the plasma<br/>membrane are only beginning to be clarified, but it is likely that transport may<br/>be an important control step for the effects of TH on transcription. Members of<br/>the recently cloned organic anion transporting polypeptide (OATP) family have<br/>been shown to transport TH. Inhibitor studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various cell types.<br/>However cloned amino acid transporters have not been studied to demonstrate<br/>directly whether they can accept TH as substrates.<br/><br/>"],"dc:identifier":["oai:discovery.dundee.ac.uk:studenttheses/4a30ffbf-102f-484f-be68-61d133333050","https://discovery.dundee.ac.uk/en/studentTheses/4a30ffbf-102f-484f-be68-61d133333050"],"dc:language":["eng"],"dc:publisher.institution":["University of Dundee"],"dc:relation.isreferencedby":["https://discovery.dundee.ac.uk/en/studentTheses/4a30ffbf-102f-484f-be68-61d133333050"],"dc:subject":["Thyroid hormones","Amino acids","membrane transport","uptake kinetics"],"dc:title":["Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Doctoral Thesis"],"dc:type.qualificationname":["Doctor of Philosophy"]},"updated_at":"2026-07-24T02:08:19Z"}