Living with Fragile X Syndrome: Occupations as an Outcome Measure in a Clinical Trial

<p>The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education and family impact. The study’s findings support the use of semi-structured interviews as an additional outcome measure in a medication trial. The qualitative methods add voice and context to the family experiences through an occupation-centered lens.</p>

Name thesis:degree_name

Master of Science in Occupational Therapy

Level thesis:degree_level

Master's Thesis

Discipline thesis:degree_discipline

Occupational Therapy

Year dc:date.available

2018

Authors dc:creator

• Chase, Theresa
• Duong, Ty
• Baldinger, Ana
• Gothelf, Kaylee

Contributors dc:contributor

• Laura Greiss Hess, PhD, OTR/L
• Julia Wilbarger, PhD, OTR/L

• Fragile X Syndrome
• medication trial
• occupational therapy
• qualitative study
• family experiences
• pediatrics
• Neurodevelopmental Disorders

Repository record dc:identifier

https://scholar.dominican.edu/masters-theses/295

OAI identifier oai:identifier

oai:scholar.dominican.edu:masters-theses-1299