The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education and family impact. The study’s findings support the use of semi-structured interviews as an additional outcome measure in a medication trial. The qualitative methods add voice and context to the family experiences through an occupation-centered lens.
","abstract_html":"<p>The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education and family impact. The study’s findings support the use of semi-structured interviews as an additional outcome measure in a medication trial. The qualitative methods add voice and context to the family experiences through an occupation-centered lens.</p>","abstract_has_math":false,"creators":["Chase, Theresa","Duong, Ty","Baldinger, Ana","Gothelf, Kaylee"],"institution":null,"degree_name":"Master of Science in Occupational Therapy","degree_level":"Master's Thesis","degree_discipline":"Occupational Therapy","degree_department":null,"school":null,"contributors":["Laura Greiss Hess, PhD, OTR/L","Julia Wilbarger, PhD, OTR/L"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-05-01T07:00:00Z","date_published":"2018-05-01T07:00:00Z","updated_at":"2026-07-24T02:04:44Z","subjects":["Fragile X Syndrome","medication trial","occupational therapy","qualitative study","family experiences","pediatrics","Neurodevelopmental Disorders"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholar.dominican.edu/masters-theses/295","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Laura Greiss Hess, PhD, OTR/L","Julia Wilbarger, PhD, OTR/L"]},{"key":"dc:creator","label":"Author","values":["Chase, Theresa","Duong, Ty","Baldinger, Ana","Gothelf, Kaylee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2022-12-01T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Occupational Therapy"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Master's Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Occupational Therapy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Fragile X Syndrome","medication trial","occupational therapy","qualitative study","family experiences","pediatrics","Neurodevelopmental Disorders"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholar.dominican.edu/masters-theses/295"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education and family impact. The study’s findings support the use of semi-structured interviews as an additional outcome measure in a medication trial. The qualitative methods add voice and context to the family experiences through an occupation-centered lens.
"]},{"key":"dc:title","label":"Title","values":["Living with Fragile X Syndrome: Occupations as an Outcome Measure in a Clinical Trial"]}]}],"canonical_facts":{"dc:contributor":["Laura Greiss Hess, PhD, OTR/L","Julia Wilbarger, PhD, OTR/L"],"dc:creator":["Chase, Theresa","Duong, Ty","Baldinger, Ana","Gothelf, Kaylee"],"dc:date.available":["2022-12-01T08:00:00Z"],"dc:description.abstract":["The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of behavior, social participation, sensory-related behaviors, receptive language, education and family impact. The study’s findings support the use of semi-structured interviews as an additional outcome measure in a medication trial. The qualitative methods add voice and context to the family experiences through an occupation-centered lens.
"],"dc:identifier":["https://scholar.dominican.edu/masters-theses/295"],"dc:subject":["Fragile X Syndrome","medication trial","occupational therapy","qualitative study","family experiences","pediatrics","Neurodevelopmental Disorders"],"dc:title":["Living with Fragile X Syndrome: Occupations as an Outcome Measure in a Clinical Trial"],"thesis:degree_discipline":["Occupational Therapy"],"thesis:degree_level":["Master's Thesis"],"thesis:degree_name":["Master of Science in Occupational Therapy"]},"updated_at":"2026-07-24T02:04:44Z"}