Dominican University of California
Efficient In Vitro Development of Photoreceptors from Human Pluripotent Stem Cells
Abstract
dc:description.abstract<p>Degeneration of the rod and cone photoreceptors in the human retina is among the most common causes of blindness. Replacing these damaged photoreceptors may help to restore vision. Repairing the damaged retina relies on the insertion of new, healthy cells. Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are two possible sources of photoreceptors to restore vision. Previous data shows that human ES cells and iPS cells can be differentiated into photoreceptors and transplanted into the eye to restore some vision. However, this process is inefficient, and costly. Here, we show a new method for inducing photoreceptor production from undifferentiated cells through the use of small molecules. Additionally, we aim to mimic retinal degenerations through oxidative stress to examine diseases such as diabetic retinopathy.</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science
- Level thesis:degree_level
- Master's Thesis
- Discipline thesis:degree_discipline
- Biological Sciences
- Year dc:date.available
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Reynolds, Joseph C.
- Contributors dc:contributor
-
- Deepak Lamba, MBBS, PhD
- Meredith Protas, Ph.D.
Subjects
dc:subject × 12Identifiers
dc:identifier.*- Repository record dc:identifier
- https://scholar.dominican.edu/masters-theses/169
- OAI identifier oai:identifier
- oai:scholar.dominican.edu:masters-theses-1169