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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 35 for “"iPS cells"”.

  1. Engineering functional kidney tissue using human iPS cells

    Elhendawi, Mona Mohamed Mostafa ElsaeedThe University of Edinburgh2020

    … enabled the derivation of renal organoids from hiPSCs; these organoids might be a powerful tool with important implications for regenerative medicine, but meticulous assessment of the functional abilities of the induced nephrons is key to the use of these organoids in any application. Here, I …

    edinburgh Repository record

  2. Analyses of hematopoiesis and lineage commitment from ES and iPS cells

    Seiler, Katharina2011

    … Analyse der Kapazitäten verschiedener ES- und iPS-Zelllinien, die sich durch die Anzahl der gebildeten erythroiden, lymphoiden und myeloiden Zellen bestimmen ließen. Es war erwartet worden, dass iPS-Zellen, die aus hämatopoietischen Knochenmarkzellen durch ektopische Expression von Sox-2, Oct-4 …

    tu-berlin Repository record

  3. Multicellular Modeling of Ciliopathy by Combining iPS cells and Microfluidic Airway-on-a-chip Technology

    Sone, NaoyukiKyoto University2021

    kyoto Repository record

  4. Mycoplasma ocular infection in subretinal graft transplantation of iPS cells-derived retinal pigment epithelial cells

    Makabe, KenichiKyoto University2019

    kyoto Repository record

  5. Endothelial Lineage Differentiation from iPS Cells is Regulated by miRNA-21/AKT and TGF-β2 Pathways

    Di Bernardini, ElisabettaKing's College London2013

    kings Repository record

  6. THE CELL CYCLE GENES REGULATION OF IPS CELLS AND THE ROLE OF SWI/SNF CHROMATIN REMODELING ENZYMES DURING THEM DIFFERENTIATION

    ROSSI, MAURIZIOUniversità degli studi di Catania2011

    Lo stato di cellula pluripotente può essere raggiunto con l'espressione ectopica di alcuni fattori di trascrizione che possono riprogrammare le cellule somatiche. (Takahashi, K., e Yamanaka, S., 2006; Takahashi, K., e Yamanaka, S., 2007).

    catania Repository record

  7. Establishment of a heart‐on‐a‐chip microdevice based on human iPS cells for the evaluation of human heart tissue function

    Abulaiti, MoshaKyoto University2022

    kyoto Repository record

  8. Using human induced pluripotent stem cells to model cystinosis

    Przepiorski, AnetaResearchSpace@Auckland2017

    … accumulation of cystine within lysosomes in most cells of the body, however the kidney is the main organ affected. For poorly understood reasons, renal proximal tubule (PT) cells lose their functionality and degenerate in cystinosis, forming a characteristic “swanneck” lesion that leads to kidney …

    auckland-ms Repository record

  9. Hematopoiesis: Functional Insights by Cell Fate Conversion

    Wahlestedt, MartinStem Cell Aging2014

    … is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in …

    lund Repository record

  10. Defining and Controlling the Subtype Identity of Human Stem Cell-Derived Motor Neurons

    Croft, Gist Fralley2012

    … cell types affected in vivo. Embryonic stem (ES) cells have the pluripotency to generate all somatic cells types, and the invention of somatic cell reprogramming techniques has allowed the creation of cell lines with both ES-cell grade pluripotency--induced pluripotent stem (iPS) cells--and the …

    columbia-diss Repository record

  11. O-linked N-acetylglucosamine in differentiation and gene expression of mouse and human pluripotent stem cells

    Domke, Tanja Carolina ElisabethUniversity of Dundee2016

    … of mouse and human embryonic stem (ES) cells. Here we show that increased levels of O-GlcNAcylation in response to specific inhibition of O-GlcNAc hydrolase (Oga) hinder mouse ES cell differentiation. In addition to these findings, I could also demonstrate that increased O-GlcNAcylation …

    dundee Repository record

  12. Efficient In Vitro Development of Photoreceptors from Human Pluripotent Stem Cells

    Reynolds, Joseph C.1970

    … retina relies on the insertion of new, healthy cells. Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are two possible sources of photoreceptors to restore vision. Previous data shows that human ES cells and iPS cells can be differentiated into photoreceptors and transplanted …

    dominican Repository record

  13. Human Stem Cells for Modeling Amyotrophic Lateral Sclerosis Disease Mechanisms and Modifiers

    Oakley, Derek Hayden2012

    … now possible to derive induced pluripotent stem cells (iPS cells) from the somatic tissues of ALS patients and then to differentiate these iPS cells into motor neurons with the precise genetic makeup of the donor patient (iPS-MNs). Before iPS-MNs can be put to productive use, however, the iPS …

    columbia-diss Repository record

  14. Novel Regulators of Somatic Cell Reprogramming

    Golipour, Azadeh2014

    Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by expression of defined embryonic factors. My thesis is focused on exploring the mechanisms underlying reprogramming using a secondary mouse embryonic fibroblast model that forms iPS cells with high efficiency upon inducible …

    toronto-retro Repository record

  15. Induced pluripotency and reprogramming by defined factors

    Carey, Bryce WMassachusetts Institute of Technology2011

    … of nuclear equivalency between adult somatic cells. However the molecular mechanisms of somatic cell reprogramming have remained largely a mystery. Recent advancements in epigenetic reprogramming by defined factors provide new opportunities to explore factors that regulate induction of …

    mit Repository record

  16. Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors

    Reinholt, Brad M.Virginia Tech2015

    Induced pluripotent stem (iPS) cells that possess embryonic stem (ES) cell-like properties are generated through the use of the Yamanaka transcription factors, OCT4, SOX2, KLF4, and MYC (OSKM). Advanced transgene delivery methods utilizing non-integrating viruses for transduction of target cells …

    vt Repository record

  17. Induced-Pluripotent Stem-Derived Neuronal Progenitor Cells As A Novel Treatment For Neurodegenerative Diseases

    Gonzalez-Romero, Dennisse A2013

    … therapies, as neuronal progenitor (NP) cells grafting, are promising therapies for patients affected with neurodegenerative diseases like Creutzfeldt-Jakob Disease (CJD). At this time there is no effective treatment or cure for CJD. The disease is inevitably fatal and affected people …

    uthsc Repository record

  18. Modularity in Somatic Cell Reprogramming

    Hernandez, Jose Javier2021

    … to achieve distinct cell fates, including stem cells. Deriving induced pluripotent stem (iPS) cells has thus emerged as a critical approach in personalized regenerative medicine that provides an exclusive platform to study human development ex utero, engineer complex tissues, and build new …

    toronto-retro Repository record

  19. Integration and function of new neurons generated from fibroblasts and adult neural stem cells in the pathological brain

    Wood, JamesLaboratory of Neurogenesis and Cell Therapy2011

    … neurons – new neurons born from neural stem cells in the adult brain, and new neurons in the sense that they were generated from fibroblasts. Papers One and Two focused on the new neurons generated from neural stem cells in the SVZ and SGZ after pathological insults. We investigated how the …

    lund Repository record

  20. Investigation of pancreatic beta cell differentiation and function, and global profiling analysis of diabetes serum for the identification of disease biomarkers

    Hennessy, EricaDublin City University2012

    … compared to glucose responsive MIN6 cells. Functional investigations involving knockdown of mir-200a, mir-130a and mir-410 in MIN6 cells exhibiting GSIS resulted in reduced GSIS. This suggested that these three miRNAs functioned in supporting the capability of MIN6 cells to secrete …

    dcu Repository record

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