Fully Coupled Fluid Structure Interaction Simulation of Bioprosthetic Heart Valves: A Numerical and Experimental Analysis

<p>Aortic stenosis impacts approximately 7% of the global population. In the past decade, the role of computational modeling has been becoming considerably important in the design of BHVs. To obtain reliable solutions in computational modeling, it is essential to consider accurate properties of bioprosthetic heart valves (BHVs), such as density and mechanical properties. Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like fixation and anti-calcification. In Chapter 2, I measured BP density and its effect on BHV leaflet stress and strain. In the second study, Chapter 3, I’ve developed a new framework to investigate the bioprosthetic heart valve (BHV) interaction with the blood flow passing through the valve inside a pulse duplicator system. This project is a major step towards the experimental validation of FSI modeling for analyzing tissue heart valves.</p>

Name thesis:degree_name

M.S.

Level thesis:degree_level

Masters Thesis

Year

2023

Author dc:creator

• Sadipour, Masod

Contributors dc:contributor

• Ali Azadani
• Matt Gordon
• Laleh Mehran

• Cardiovascular mechanics
• Data analysis
• Fluid structure analysis
• Heart valves
• Hemodynamics
• Numerical analysis
• Biomechanical Engineering
• Biomedical Devices and Instrumentation
• Biomedical Engineering and Bioengineering
• Engineering
• Mechanical Engineering

Statement dc:rights

• <p>Copyright is held by the author. User is responsible for all copyright compliance.</p>

Language dc:language

English (eng)

Repository record dc:identifier

https://digitalcommons.du.edu/etd/2321

OAI identifier oai:identifier

oai:digitalcommons.du.edu:etd-3308