Design Rules for the Nucleation, Growth, and Encapsulation of Gold Nanoparticles with Applications to Cancer Imaging

<p>Surface-enhanced Raman scattering (SERS) nanoparticles are exciting candidates for high-precision cancer imaging due to their highly specific spectral signature (Raman “fingerprint”) and propensity for passive targeting of cancerous tissues. However, the signal intensity of currently available SERS nanoparticles is insufficient for cancer imaging via passive targeting in most solid tumors. The overarching aim of this body of work is to develop a new generation of SERS nanoparticles with sufficiently low limits of detection to enable robust detection of various solid tumors <em>in vivo</em>.</p> <p>The complexity of SERS nanoparticles requires significant advances to the theoretical and experimental understanding of metal nanoparticle syntheses and the methods of their encapsulation if optimized constructs are to be achieved. In particular, the requirement that the Raman-active molecules adsorb to the metal nanoparticle for maximum surface enhancement necessitates nucleation, growth and encapsulation methods that maximize the potential for metal-molecule binding. This poses a substantial roadblock to overcoming the current limitations of SERS nanoparticle intensity, because metal nanoparticle syntheses rely upon surface-passivating surfactants or polymers to enable morphological control. Moreover, metal nanoparticles typically require priming of their surface with silicate or polymer layers to ensure successful encapsulation under high ionic strength (e.g., from the presence of Raman-active molecules and counterions). These challenges make the optimization of SERS nanoparticles a case study in the theoretical and experimental frontiers of nanoparticle engineering.</p>

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Chemistry

Grantor

The Graduate School and University Center of The City University of New York

Year dc:date.available

2016

Author dc:creator

• Wall, Matthew A

Advisors dc:contributor.advisor

• Charles Michael Drain
• Moritz F. Kircher

Committee members dc:contributor.committeemember

• John Lombardi
• Stephen O'Brien
• Jason Lewis

• Chemistry
• Materials Chemistry
• Nanotechnology
• Radiochemistry
• Nucleation Theory
• Crystal Growth
• Surface-Enhanced Raman Scattering
• Gold
• Silica
• Cancer Imaging

Repository record dc:identifier

https://academicworks.cuny.edu/gc_etds/778

OAI identifier oai:identifier

oai:academicworks.cuny.edu:gc_etds-1793