Derivatives of 1-(3-methoxy-4-acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5

Papadakis has synthesized the following substances: 1-(p-Acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5 (I), 4-Hydroxphenyl-cyclohexanedione-3,5 (II), l-(p-Acetoxyphenyl)-2,6-dicarbethoxy-4-carbethoxymethyl-cyclohexanedione-3,5 (III), which are good starting materials for the further synthesis of substitutes for cardiac glycosides (IV) and hormones because they have the necessary functional groups in proper locations.|Papadakis and Scigliano have also synthesized 1-(3-Methoxy-4-acetoxyphenyl)-2,6-dioarbethoxy-cyclohexane- dione-3,5 (VII). They reacted vanillin with diethyl malonate to form Ethyl- (3-Methoxy-4-hydroxy)-benzalmalonate (v). (V) was acetylated to form Ethyl-(3-Methoxy-4-acetoxy)-benzalmalonate (V). (V) was reacted with acetoacetic ester and sodium ethoxide to give (VII). The object of this investigation is to prepare derivatives of (VII) which may be of physiological importance. In this research the preparation of a dye and a sulfone gives a beginning to further research in the two fields of dyes and sulfones. It is known that some dyes are of pharmaceutical as well as industrial importance, such as prontosil. Lately sulfones have attracted more attention since 4,4'-diamino-diphenylsulfone has been shown to have effect against tuberculosis and leprosy.

Grantor dc:publisher

Creighton University

Year dc:date.issued

1949

Authors dc:creator

• Adrian, M. Adrienne, S.S.N.D.
• Adrian, M. Adrienne

Advisor dc:contributor.advisor

• Papadakis, Phillippos E.

Language dc:language.iso

en_US

Dc Identifier Other

RAL Thesis 1949 A37

OAI identifier oai:identifier

oai:cdr.creighton.edu:10504/69107