Derivatives of 1-(3-methoxy-4-acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5
type: CreativeWork
description: Papadakis has synthesized the following substances: 1-(p-Acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5 (I), 4-Hydroxphenyl-cyclohexanedione-3,5 (II), l-(p-Acetoxyphenyl)-2,6-dicarbethoxy-4-carbethoxymethyl-cyclohexanedione-3,5 (III), which are good starting materials for the further synthesis of substitutes for cardiac glycosides (IV) and hormones because they have the necessary functional groups in proper locations.|Papadakis and Scigliano have also synthesized 1-(3-Methoxy-4-acetoxyphenyl)-2,6-dioarbethoxy-cyclohexane- dione-3,5 (VII). They reacted vanillin with diethyl malonate to form Ethyl- (3-Methoxy-4-hydroxy)-benzalmalonate (v). (V) was acetylated to form Ethyl-(3-Methoxy-4-acetoxy)-benzalmalonate (V). (V) was reacted with acetoacetic ester and sodium ethoxide to give (VII). The object of this investigation is to prepare derivatives of (VII) which may be of physiological importance. In this research the preparation of a dye and a sulfone gives a beginning to further research in the two fields of dyes and sulfones. It is known that some dyes are of pharmaceutical as well as industrial importance, such as prontosil. Lately sulfones have attracted more attention since 4,4'-diamino-diphenylsulfone has been shown to have effect against tuberculosis and leprosy.
abstract: Papadakis has synthesized the following substances: 1-(p-Acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5 (I), 4-Hydroxphenyl-cyclohexanedione-3,5 (II), l-(p-Acetoxyphenyl)-2,6-dicarbethoxy-4-carbethoxymethyl-cyclohexanedione-3,5 (III), which are good starting materials for the further synthesis of substitutes for cardiac glycosides (IV) and hormones because they have the necessary functional groups in proper locations.|Papadakis and Scigliano have also synthesized 1-(3-Methoxy-4-acetoxyphenyl)-2,6-dioarbethoxy-cyclohexane- dione-3,5 (VII). They reacted vanillin with diethyl malonate to form Ethyl- (3-Methoxy-4-hydroxy)-benzalmalonate (v). (V) was acetylated to form Ethyl-(3-Methoxy-4-acetoxy)-benzalmalonate (V). (V) was reacted with acetoacetic ester and sodium ethoxide to give (VII). The object of this investigation is to prepare derivatives of (VII) which may be of physiological importance. In this research the preparation of a dye and a sulfone gives a beginning to further research in the two fields of dyes and sulfones. It is known that some dyes are of pharmaceutical as well as industrial importance, such as prontosil. Lately sulfones have attracted more attention since 4,4'-diamino-diphenylsulfone has been shown to have effect against tuberculosis and leprosy.
author: Adrian, M. Adrienne, S.S.N.D.
author: Adrian, M. Adrienne
language: en_US
date published: 1949
date modified: 2026-07-24T01:50:24Z
provider: Creighton University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Creighton University

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property ID: Handle
value: http://hdl.handle.net/10504/69107