Available fluoride ion in solution and one minute fluoride release rate of a toothpaste formulation

Damaged enamel of an early carious lesion can be repaired through the body’s natural repair process known as remineralization. For remineralization to occur, bioavailable calcium, phosphate, and fluoride ions must be present at the surface of the tooth. Toothpaste products supply bioavailable fluoride ions to the oral cavity. Calcium and phosphate ions are supplied primarily through the saliva, but in limited quantity. In this research, calcium nitrate salt and potassium phosphate dibasic salt solutions were encapsulated in microcapsules and formulated with toothpaste. The microcapsules rupture upon brushing, releasing bioavailable calcium, phosphate, and fluoride ions for remineralization. Total available fluoride and one minute fluoride release rates tests were performed to ensure that these new formulations will meet the requirements for the FDA monograph for over the counter anticaries products and the ADA Seal of Acceptance. Results for these two tests indicate that these formulations meet the requirements for the FDA and ADA. The microcapsule approach shows promising potential to become a novel delivery platform for bioavailable calcium and phosphate ions that aid in remineralization.

Grantor dc:publisher

Creighton University

Year dc:date.issued

2014

Author dc:creator

• Mueller, Elizabeth

Advisor dc:contributor.advisor

• Gross, Stephen M.

Statement dc:rights

• Copyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10504/49614

OAI identifier oai:identifier

oai:cdr.creighton.edu:10504/49614