Selection and Characterization of Strains of Staphylococcus aureus Displaying Unusual Resistance to Aminoglycosides

Studies concerning the effects of procedural variations on the activity of aminoglycosides have revealed that a single procedural change can significantly alter results, particularly in tests with Staphylococcus aureus (116,123). Variations in such factors as inoculum and type of medium used may at times also alter the clinical interpretation of results, and significant discrepancies between the minimal inhibitory concentrations and minimal bactericidal concentrations of aminoglycosides have been observed (62,90,116). These observations suggest the presence of a small subpopulation of cells within the sensitive parent strain which are more resistant to the effects of the aminoglycoside. Therefore, the purpose of this study was to (a) evaluate the bactericidal activity of aminoglycosides against Staphylococcus aureus by the use of kill curves (b) characterize the more resistant cells selected from strains of Staphylococcus aureus which appeared to be sensitive to aminoglycosides by minimal inhibitory concentration determinations, and (c) determine the prevalence of strains containing these more resistant cells.

Grantor dc:publisher

Creighton University

Year dc:date.issued

1976

Author dc:creator

• Wilson, Stephen G.

Advisor dc:contributor.advisor

• Sanders, Christine C.

• Microbiology

Statement dc:rights

• A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10504/118429

OAI identifier oai:identifier

oai:cdr.creighton.edu:10504/118429