Manometric Studies of Earle's Strain L Sarcoma Cells

In his classic report, "Metabolism of Tumors" in 1925, Warburg postulated several generalizations concerning malignant tumor tissue metabolism, and summarized from his studies that "interference with the respiration in growing cells is, from the standpoint of the physiology of metabolism, the cause of tumors. If the respiration of a growing cell is disturbed, as a rule the cell dies. If it does not die, a tumor cell results."(1) Although the Respiratory interference as the cause of tumors is no longer held as the primary cause (2,3,4), generalized metabolic characteristics of 1) low oxygen uptake rates, 2) high aerobic glycolysis, and 3) high anaerobic glycolysis reported by Warburg have been found by later workers (5,6,7,8) to be descriptive of all malignant tumor tissue enabling a classification of what is or is not cancer tissue by metabolic measurements on tissue slices.

Grantor dc:publisher

Creighton University

Year dc:date.issued

1955

Author dc:creator

• Feldhaus, Richard J.

Advisor dc:contributor.advisor

• Phillips, Hugh J.

Statement dc:rights

• A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10504/116026

OAI identifier oai:identifier

oai:cdr.creighton.edu:10504/116026