Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 214 for “"Sarcoma"”.
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Genetic Profiling in Soft Tissue Sarcoma
Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors …
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Modelling RANBP2-ALK-rearranged Epithelioid Inflammatory Myofibroblastic Sarcoma
Epithelioid inflammatory myofibroblastic sarcoma (eIMS) is an aggressive variant of inflammatory myofibroblastic tumour characterised by ALK staining that is perinuclear or cytoplasmic with perinuclear accentuation, CD30 expression and early relapse despite crizotinib treatment [1, 2]. This study …
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Synovial sarcoma : translating gene expression into patient care
Synovial sarcoma is a soft tissue tumor defined by the presence of t(X;18)(p11.2;q11.2), fusing the SYT (SS18) gene on chromosome 18 and one of three SSX genes on chromosome X. T(X;18) results in production of a fusion protein (SYT-SSX) that is thought to underlie synovial sarcoma pathogenesis …
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Clinical and Biological Patterns in Soft Tissue Sarcoma
Soft tissue sarcomas (STSs) are rare malignant tumors, of which 3/4 are high-grade and 1/3 metastasize. For optimal management, STSs should be treated at multidisciplinary sarcoma centers. Study I demonstrated that simple referral guidelines, an open-access outpatient clinic and repeated educative …
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Manometric Studies of Earle's Strain L Sarcoma Cells
In his classic report, "Metabolism of Tumors" in 1925, Warburg postulated several generalizations concerning malignant tumor tissue metabolism, and summarized from his studies that "interference with the respiration in growing cells is, from the standpoint of the physiology of metabolism, the cause …
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Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. In study I, we demonstrated that 20% of the patients …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a rare and highly aggressive soft tissue sarcoma with vast unmet treatment needs, both in curative options and the prolongation of survival. The heterogeneity and limited understanding of the targetable alterations within UPS have proven to be …
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Walleye dermal sarcoma virus Orf C: a potential oncolytic therapy
… included species is presented. Walleye dermal sarcoma virus (WDSV) is a complex retrovirus that causes the growth of multifocal, cutaneous tumors in walleye fish (Sander vitreus vitreus). These virus-induced tumors spontaneously regress on a seasonal basis. The WDSV genome encodes three …
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Identification of EWS-FLI1 Regions Necessary for Ewing Sarcoma Proliferation
Ewing sarcoma is pediatric bone malignancy defined by a translocation between EWS and ETS family transcription factor. EWS-FLI1 (EF) is the most common translocation and codes for a novel transcription factor that combines the N-terminus of EWS, which contains LC domain comprised of tyrosine rich …
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Targeting Histone Deacetylases (Hdac) For The Treatment of Soft Tissue Sarcoma
… of genetically complex soft tissue sarcoma</strong></p> <p>Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of HDAC isoform activity in soft tissue sarcoma (STS). We investigated the …
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Evaluation of resting energy expenditure in sarcoma patients with localized disease
… methods were then applied to seven male sarcoma patients with localized disease. Only the age and sex-matched group of controls were compared to the sarcoma patient group. All patients had received no prior cancer treatment. Body composition assessment included measurement of body fat …
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An evaluation of 99mTc-MIBI imaging of Kaposi's Sarcoma in AIDS patients
Thesis (Doctor in Technology: Radiography), Durban Institute of Technology, Durban, South Africa, 2006
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Genetic and Biochemical Analysis of the Bryan Strain of Rous Sarcoma Virus
<p>Integration of Rous sarcoma virus DNA into its host genome was analyzed under conditions where secondary integration via virus spread was inhibited. This was accomplished by using the noninfectious pol<sup>-</sup>, env<sup>-</sup> alpha variant of the Bryan high titer strain of Rous sarcoma …
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Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
… the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The study …
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Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product
<p>Four previously uncharacterized avian sarcoma viruses were screened and two of these, RPL30 and CT10, were found to encode apparently novel oncogenes. Biologically active CT10 DNA was molecularly cloned and the nucleotide sequence was determined. The CT10 genome encodes a gag-fusion polypeptide …
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