Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids

DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. Unfortunately, the high levels of hepatotoxicity induced by these compounds negates their effectiveness as antitumor agents. Modification of the chemical structure of the pyrrolizidine core could yield compounds with potent antitumor activity and reduced hepatotoxicity. The synthesis of a class of potential pyrrolizidine progenitors developed from monocrotaline is discussed. The synthesis of a potential water soluble photolabile protecting group is also described. In addition, the biological evaluation of the synthesized pyrrolizidine progenitors was investigated.

Name thesis:degree_name

Master of Science (M.S.)

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Chemistry

Grantor dc:publisher

Colorado State University. Libraries

Year dc:date.issued

2001

Authors dc:creator

• Kosogof, Christi, author
• Williams, Robert M., advisor

• Pyrrolizidines
• Antineoplastic agents

Statement dc:rights

• Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.

Language dc:language.iso

eng, English

Identifier URI

https://doi.org/10.25675/3.018777

OAI identifier oai:identifier

oai:mountainscholar.org:10217/235859