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Intramolecular [4+1] pyrroline annulation as a general method for the synthesis of pyrrolizidine alkaloids

Frazier, James OwenVirginia Polytechnic Institute and State University1986

… dienes with subsequent pyrolyses to provide the pyrrolizidines of type 3. This study broadened the scope of the vinylogous Reformatsky reaction to include the preparation of alkaloid synthons and introduced the heteroatom equivalent of the carbenoid [4+1] annulation as a method or alkaloid …

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The synthesis of pyrrolizidine alkaloids

Neuenschwander, Kent1982

… of several pyrrolizidine alkaloids;The simple pyrrolizidines, trachelanthamidine and isoretronecanol, were prepared from succinimide. The synthesis required only five steps and proceeded in good overall yield. The synthesis is the most direct and operationally convenient route yet reported;An …

iastate Repository record for The synthesis of pyrrolizidine alkaloids (opens in a new tab)

Synthesis of pyrrolizidine diols via azide-diene cycloadditions

Seoane, Gustavo A.Virginia Polytechnic Institute and State University1988

… rearrangement of several derivatives of 234 to pyrrolizidines 239, 241, and 242. A study of the thermal decomposition of oxygenated azidodienes such as 196 and 233 was carried out. Conclusive results regarding the stereochemical control of the C-7 substituent were attained and used for the …

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Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids

Kosogof, Christi, author, Williams, Robert M., advisorColorado State University. Libraries2001

DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. …

colostate Repository record for Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids (opens in a new tab)

I. SYNTHETIC APPLICATIONS OF CARBANIONS DERIVED FROM GLYCOLATES--STUDIES DIRECTED TOWARD THE SYNTHESIS OF VITAMIN-C; II. CRYSTAL AND MOLECULAR STRUCTURE OF SYN-9-HYDROXY-1-AZA-4-OXATRICYCLO (3.2.1.1(3,8)) - NONANE--A BRIDGED PYRROLIZIDINE

Deardorff, Donald RossThe University of Arizona.1979

arizona-thes Repository record for I. SYNTHETIC APPLICATIONS OF CARBANIONS DERIVED FROM GLYCOLATES--STUDIES DIRECTED TOWARD THE SYNTHESIS OF VITAMIN-C; II. CRYSTAL AND MOLECULAR STRUCTURE OF SYN-9-HYDROXY-1-AZA-4-OXATRICYCLO (3.2.1.1(3,8)) - NONANE--A BRIDGED PYRROLIZIDINE (opens in a new tab)

Synthesis of the bicyclic core of pyrrolizidine alkaloids

Tuluoglu, Fatmagul

<p>Pyrrolizidine alkaloids are a large class of natural products whose members exhibit a variety of biological properties including potential applications toward the treatment of cancer, diabetes, and viral infections such as HIV. In addition, some of these compounds exhibit insect antifeedant …

emich Repository record for Synthesis of the bicyclic core of pyrrolizidine alkaloids (opens in a new tab)

Controlling the diastereoselectivity in the microwave-assisted aza-cope rearrangement--Mannich cyclization

Turley, Wesley A2007

emich Repository record for Controlling the diastereoselectivity in the microwave-assisted aza-cope rearrangement--Mannich cyclization (opens in a new tab)