STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control

The cGAS-STING pathway is widely recognized as a central mediator of innate immune responses to cytosolic DNA. However, whether cGAS-STING directly coordinates DNA damage response in non-immune cells and thereby contributes to cell-intrinsic prevention of oncogenesis is not known. The present work uncovers a novel role and identifies STING as an epithelial, interferon-independent genome-integrity checkpoint that couples DNA damage signaling to cell-cycle control, thereby restraining chromosomal instability, tumor evolution, and providing a therapeutically exploitable vulnerability in cancer therapy.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Christian-Albrechts-Universität zu Kiel

Year

2026

Author dc:creator

• Xiang, Hang

Contributors dc:contributor

• Aden, Konrad
• Peifer, Christian

• STING
• DNA damage repair
• CDK1
• Cancer

Repository record source_url

https://macau.uni-kiel.de/receive/macau_mods_00008603

OAI identifier oai:identifier

oai:macau.uni-kiel.de:macau_mods_00008603