Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"STING"”.
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Sting of the Gallfly
<p>This thesis contains the first volume of <em>Sting of the Gallfly, </em>a work of fantasy fiction with a setting inspired by marginalia in gothic medieval manuscripts. A child’s drawing comes to life with a dangerous appetite, causing her to flee her monastic home. She meets a thief on the road …
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Probing corruption: Elite perceptions of sting operations
This thesis examines whether a governmental elite consensus exists that the nature of public corruption in the Las Vegas Valley justifies the use of federal law enforcement undercover operations. Using the elite interviewing method, the writer obtained the perceptions of twenty-four sworn public …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
The cGAS-STING pathway is a vital component of innate immunity. In addition to its well-established role in inducing proinflammatory cytokines, activation of the pathway also induces noncanonical autophagy. Despite an increasing body of research on STING-induced noncanonical autophagy, our …
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STING Signaling in Adaptive Immunity and Respiratory Physiology
The author publishes under the names Kennady Knox and Kennady Abbott.
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Regulation of the cGAS-STING Pathway in Health and Disease
Pages v-xiii are misnumbered as pages vi-xiv.
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… Synthase- Stimulator of Interferon Genes (cGAS-STING) pathway is one of the primary methods of producing Type I IFNs; therefore, this work sought to evaluate the role of the cGAS-STING pathway in a murine controlled cortical impact (CCI) model of TBI. Using cGAS knockout (KO) or STING KO mice, …
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The Role of the cGAS-STING Pathway in Cancer and Autoimmunity
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
… component stimulator of interferon genes (STING) could reprogram tumor associated macrophages (TAMs) and myeloid derived suppressor cells (MDSCs) to support rather than suppress T cell activity, converting CRPC and PDAC to settings in which checkpoint blockade can be effective. To this end, …
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Tumor-Specific STING Agonist Synthesis via a Two-Component Prodrug System
Pharmacological activation of STING holds promise in cancer treatment. A recent trend is the development of tumor-specific or conditionally activated STING agonists for enhanced safety and efficacy. Herein, we explored an unconventional prodrug activation strategy for on-tumor synthesis of a potent …
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Regulation of the cGAS-STING Pathway: Non-Agonist Activation and Cellular Trafficking
The cGAS-STING pathway in the innate immune system plays an important role in infection and cancer. Exogenous or endogenous DNA and cyclic dinucleotides acutely activate cGAS-STING, leading to type I interferon (IFN) signaling. STING-mediated IFN signaling is dynamically regulated by STING …
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Treatment of musculoskeletal pain with the sting of the stinging nettle: Urtica dioica
… interest in the therapeutic potential of the sting of nettles began with the presentation of two patients in his general practice surgery who were self-prescribing nettle sting for their arthritis pain. The publication of these two case reports produced responses from four other doctors about …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
The cGAS-STING pathway is widely recognized as a central mediator of innate immune responses to cytosolic DNA. However, whether cGAS-STING directly coordinates DNA damage response in non-immune cells and thereby contributes to cell-intrinsic prevention of oncogenesis is not known. The present work …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… by combining two different classes of adjuvants, STING and TLR 7/8 agonists because of their distinct immune cell targets, signaling pathways, and significant roles in the activation and maintenance of immune responses. STING and TLRs are pattern recognition receptors that act as sensors for …
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Delivery of sting agonist using lipid nanoparticles and discovery of anti-TIGIT peptides for cancer therapy
… above. The first research aims to deliver a STING agonist into a cold tumor using lipid nanoparticles. This delivery is intended to provoke an immune response that leads to the elimination of tumor cells. STING pathway agonism has shown promise in innate immune signaling to tune the tumor …
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Comparison of Strain Gage and Fiber Optic Sensors On A Sting Balance In A Supersonic Wind Tunnel
… of aerodynamic properties during wind tunnel testing. With the recent advancements of technology, new fiber optic sensors have been designed to replace the conventional foil strain gage sensors commonly found on balances, thereby offering several distinct advantages. The use of fiber optic …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor types. Immunologically "cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC), remain clinically unresponsive to …
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Inheritance, innovation, and adaptation of immune systems: Regulation of the Innate Immunity Sensor Stimulator of Interferon Genes (STING)
… from bacteria. Using the innate immune protein STING as an example, which exhibits conserved domains from bacteria to humans, we investigated how the activity of human STING is regulated both similarly and differently compared to its bacterial counterpart. Similar to bacterial STING, the …
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A Host Regulatory Circuit of HSV Gene Expression
… During this complex process, HSV-1 triggers STING, a host factor that inhibits viral infection. It is well established that STING mediates antiviral immunity by inducing type I IFN. Additionally, STING activates autophagy to regulate HSV-1 replication. While poorly understood, STING is also …
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
… adapter STimulator of INterferon Genes (STING). Activated STING initiates transcription of the anti-viral cytokine interferon-b, and by extension, induces activation of the anti-viral immune response. Other DNA sensors have been proposed to recognise exogenous DNA via STING but their …
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To start or not to start: that is the question
… viscous flow and a 5.5-inch diameter cone with sting and or sting and support the tunnel would unstart. Secondary findings determined that viscous flow and sting and or sting and sting support are essential to the results. The tunnel unstarts due to shock and boundary layer interaction on the …
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