Carleton University
Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
Abstract
dc:description.abstractPreclinical and clinical evidence suggests that cannabis, a potent cannabinoid, has potential analgesic properties. However, there is a gap in the literature in respect to cannabinoid receptor expression and localization in the spinal cord across both sex and species, with almost nothing known in humans. We used immunohistochemistry and confocal imaging to investigate the differential expression of the cannabinoid type 1 receptor (CB1R) across dorsal horn laminae and cell populations in male and female adult rats and humans. Qualitatively, we observed increased neuropil immunostaining in the SDH of rats and humans, and somatic staining in deeper laminae. Quantitative results indicated a significant increase in CB1R immunoreactivity in the SDH when compared to the deeper dorsal horn laminae of male and female rat and humans. The preferential expression of CB1Rs in the SDH across both sex and species has significant implications for both the understanding and treatment of pain.
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.Sc.)
- Level thesis:degree_level
- Master's
- Discipline thesis:degree_discipline
- Neuroscience
- Grantor dc:publisher
- Carleton University
- Year dc:date.issued
- 2022
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Parnell, Jessica Marie
Rights
dc:rights- Statement dc:rights
-
- Copyright © 2022 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:carleton.scholaris.ca:20.500.14718/42784