Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"SDH"”.
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A low-cost design of multiservice SDH networks with multiple constraints
… problem of ring-node assignment a Multiservice SDH/SONET Optical network design with constraints in capacity and differential delay. The problem is characterized as a graph-partitioning problem, and a heuristic algorithm based on constraints programming satisfaction technology is proposed.
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Topology overlays for dedicated protection Ethernet LAN services in advanced SONET/SDH networks
… large sums to transition their legacy' SONET/SDH voice-based networking infrastructures to better support client-side Ethernet data interfaces, i.e., next-generation SONET/SDH (NGS). In particular, a key addition here has been the new virtual concatenation (VCAT) feature which supports inverse …
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Developing drugs to attenuate succinate accumulation and oxidation
… of IR injury, with succinate dehydrogenase (SDH) a major player in orchestrating the damage. Succinate accumulates during ischaemia and is rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), leading to cellular death. I have investigated the development of …
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The use of clinical, behavioral, and social determinants of health to improve identification of patients in need of advanced care for depression
… behavioral, and social determinants of health (SDH) that inform the onset, progression, and outcome of depression. We leveraged the depression taxonomy to build decision models that predicted need for referrals across: (a) the overall patient population and (b) various high-risk populations. …
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Improving Equity In Atherosclerotic Cardiovascular Disease Risk
… codes 55 – 65 describe social drivers of health (SDH) like housing, economics, and social systems which complicate care. Development of the ASCVD risk assessment and management protocol (ASCVD-RAMP) assessed ASCVD risk without race modification in patients aged 45 – 75 and improved health equity …
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A place to cook: A scoping review
… address multiple social determinants of health (SDH) from an intersectoral approach. We used Arksey and O’Malley (2005) scoping review design and Dahlgren and Whitehead’s (2007) SDH as a conceptual framework. The most prominent drivers shaping health that are associated with housing and food …
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Efeito da amônia sobre as convulsões e a inibição da sucinato desidrogenase induzidas por ácido metilmalônico
… por inibição da sucinato desidrogenase (SDH), muito pouco se sabe sobre a contribuição da hiperamonemia para o desenvolvimento das convulsões nestes pacientes. No presente estudo investigou-se os efeitos do acetato de amônio sobre a ação convulsivante do MMA in vivo e do cloreto de amõnio …
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Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
… increased neuropil immunostaining in the SDH of rats and humans, and somatic staining in deeper laminae. Quantitative results indicated a significant increase in CB1R immunoreactivity in the SDH when compared to the deeper dorsal horn laminae of male and female rat and humans. The …
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Efeito da fenilalanina e da alanina sobre as atividades dos complexos da cadeia respiratória de córtex cerebral de ratos
… mitocondrial (CCR) e succinato desidrogenase (SDH) no córtex cerebral de ratos Wistar sujeitos à hiperfenilalaninemia (HPA) quimicamente induzida e à administração crônica de Ala, desde o 6± até o 21± dia de vida pós-natal. Também investigamos o efeito in vitro da Phe e Ala nas atividades da …
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Oncometabolitos: relevancia en la respuesta al daño en el ADN.
… hidratasa (FH) y succinato deshidrogenasa (SDH), respectivamente. Esta acumulación causa la proliferación celular descontrolada y la transformación tumoral de las células. Por esta razón, estos compuestos se describen como oncometabolitos, y los enzimas FH y SDH como supresores tumorales. …
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A study of succinate dehydrogenase deficient tumourigenesis: From functional assessment of variant pathogenicity to the discovery of new disease biomarkers
… cycle enzyme complex succinate dehydrogenase (SDH) is associated with a predisposition to a spectrum of tumourigenesis including phaeochromocytoma, paraganglioma (1) (PPGL), gastrointestinal stromal tumours (GIST) (2), renal cell carcinoma (RCC) (3) and pituitary adenomas (4). Pathogenic …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… the respiratory complex succinate dehydrogenase (SDH) has been identified as a new therapeutic target. The mitochondrial metabolite succinate accumulates during ischaemia, before being rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), and leading to oxidative …
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Performance Analysis of a Binary-Tree-Based Algorithm for Computing Spatial Distance Histograms
… challenging tasks. Spatial Distance Histogram (SDH) is one of the most popular queries being used in this field. In this thesis, we are interested in investigating the performance of improvement of an existing algorithm for computing SDH. The algorithm already being used is using a conceptual …
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Metabolic profile of myosin heavy chain-based fiber types in the rat soleus after spinal cord transection
… analyses for succinate dehydrogenase (SDH, oxidative marker) and a-glycerophosphate dehydrogenase (GPD, glycolytic marker) activities (~30 fibers/muscle) and immunohistochemical analysis for MHC isoform composition. The total number of soleus fibers analyzed was ~900. Oxidative capacity …
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The molecular characterisation of the recA locus in the opportunistic pathogen Bacteroides fragilis
… was a putative saccharopine dehydrogenase gene (sdh), encoding the SDH protein which may be involved in lysine degradation. The second ORF, BF638R1246/7 had homology to bcp genes, and encoded a putative Bactoferritin co-migratory protein (BCP) belonging to the thiol specific antioxidant …
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Modulation of synaptic transmission by TRP channels
… afferents terminate in spinal cord dorsal horn (SDH) and caudal spinal trigeminal nucleus (CSTN). Neurotransmitter release from first order nerve terminals regulates ascending sensory transmission. Several lines of evidence indicate that plasticity in the spinal cord dorsal horn underlies …
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The Effect of Post-Injury Exercise Training on Skeletal Muscle Mitochondria
… endurance treadmill running. Fibre type-specific SDH (succinate dehydrogenase) content of type I, IIa, IIx and IIa/IIx fibres was compared between activity groups (sedentary vs exercise trained) at 14 and 50 days post-cardiotoxin-induced injury. Interestingly, 14 days of endurance exercise after …
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Skeletal muscle morphology and function in former elite distance runners : a 20 year follow-up
… high intensity running, succinate dehydrogenase (SDH) activity and type I and type II muscle fiber areas were similar between evaluations. In 1993, the HI group had higher (p<0.05) SDH and citrate synthase (CS) activities compared with the FIT and UT groups, whereas phosphorylase activity did not …
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HIV-Polymyositis progressing to inclusion body myositis: clues to earlier diagnosis
… and mitochondrial abnormalities (i.e COX – /SDH + fibres) were noted in all four patients in whom immunohistochemical staining and combined SDH and COX staining were performed. At the visit to neurology, five patients could be categorized as clinically defined IBM and four were defined as …
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Análisis genético de paragangliomas de cabeza y cuello
… estudiándose además las mutaciones en los genes SDHB, SDHC, SDHD, RET Y VHL en pacientes que presentaban PGL de cabeza y cuello. Una vez realizado el análisis mutacional de todos los genes implicados en los PGLs familiares y establecida la correlación con los datos clínicos, se estudió la …
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