Carleton University
Truncated Tyrosine Kinase Receptor B (TrkB.T1) plays a role in susceptibility to chronic stress
Abstract
dc:description.abstractBrain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) have been implicated in depressive/anxiety disorders. The efficacy of antidepressants may be related to BDNF-TrkB signaling fueling neuroplastic changes. TrkB.T1 might have novel signaling effects that may be relevant for dealing with stressors. Using mice lacking TrkB.T1 exposed to chronic stress, we assessed behavioral and TrkB expression profiles, as well as gut-microbial profile. Our results showed that while repeated different stressor regimen did markedly alter open-field performance, this was unaffected by the TrkB.T1 knockout. A sex effect was apparent, however male mice showed the greatest exploration abnormalities. TrkB expression in amygdala varied as a function of sex; yet, there were no observed difference in the gut microbiota among the groups. These data do not support major role for TrkB.T1 in modulating anxiety, but there were many limitations of this thesis study. Further experiments will focus on the phenotype of TrkB.T1 mice.
Degree
thesis:*- Name thesis:degree_name
- Master of Science (M.Sc.)
- Level thesis:degree_level
- Master's
- Discipline thesis:degree_discipline
- Neuroscience
- Grantor dc:publisher
- Carleton University
- Year dc:date.issued
- 2020
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Khalaf, Sara
Rights
dc:rights- Statement dc:rights
-
- Copyright © 2020 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:carleton.scholaris.ca:20.500.14718/41487