Global ETD Search
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Showing 1 to 20 of 46 for “"TrkB"”.
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TrkB and gene expression
… for TrkA, BDNF and NT4/5 are preferred for TrkB, and NT3 for TrkC, although NT3 also binds with less affinity to TrkA and TrkB. During my PhD I have focused my interest in understanding how neurotrophins regulate gene expression and, in particular, how BDNF does this through its high …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
… of its receptor, tropomyosin receptor kinase B (TrkB). Studies indicate that the loss of TrkB specifically in the NAc shell reduced the reinforcing effects of cocaine using a self-administration paradigm, and also psychomotor effects of cocaine on activity; however, the contributions of each …
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… its major receptor, Tyrosine receptor kinase B (TrkB). In the developing brain, BDNF acts as a guidance cue influencing the direction of the axonal growth cone. In the mature brain, it ensures survival of neurons and synaptic plasticity. Guidance cues remodel the nascent local proteome in the …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
<p><strong>Delineating the mechanism(s) of BDNF/TrkB mediated proliferation in Neuroblastoma</strong></p> <p> Timothy Christopher Graham, B.S.</p> <p>Supervisory Professor: Patrick Zweidler-McKay, MD/PhD</p> <p> Neuroblastoma is the most common extra-cranial solid tumor in children, arising from …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… functions through tyrosine kinase receptor TrkB, the functional effects of tyrosine kinase receptor TrkB on the striatal DA release and uptake rate were examined. This work utilized FSCV to evaluate the effect of exogenous BDNF, TrkB agonist; 7,8-dihydroxyflavone (7,8-DHF), and TrkB …
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BDNF-TrkB Signaling in Efficacy of CA3-CA1 Synapses and Ketamine-Mediated Antidepressant Effects
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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A Role for BDNF-Trkb Signaling in the Modulation of Superoxide Dismutase-1 Expression
… via a cDNA expression screen, that the TrkB receptor and the guanine nucleotide exchange factor, RasGRF-1, modulate SOD1 expression at the protein level, suggesting that cell signaling pathways associated with TrkB signaling are involved in regulating the expression of SOD1. …
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Use it and boost it: cognitive and physical activities modulate cognition via BDNF-TrkB signaling
… physical activity increased BDNF protein, BDNF-TrkB signaling, and BDNF release in the hippocampus and striatum. Our studies show that priming the brain with cognitive and physical activities enhance hippocampus- and striatum-sensitive learning via BDNF-TrkB signaling. In addition, we found that …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… is through the muscle-synthesized BDNF (msBDNF) /TrkB-mediated Bcl-2 nineteen-kD interacting protein (BNIP3) mitophagy pathway, although the relationship is not well-defined. BNIP3 localizes to the mitochondria and triggers a loss of membrane potential leading to mitochondrial destruction. Using a …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene …
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Role of Tyrosine Receptor Kinase B in the Development and Function of the Central Nervous System
Tyrosine Receptor Kinase B (TrkB) was initially identified as the high-affinity receptor for Brain-Derived Neurotrophic Factor (BDNF) in regulating the survival of sympathetic and sensory neurons. In the CNS, however, BDNF-TrkB interaction has been shown to regulate diverse aspects of development, …
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Truncated Tyrosine Kinase Receptor B (TrkB.T1) plays a role in susceptibility to chronic stress
… factor (BDNF) and tyrosine kinase B (TrkB) have been implicated in depressive/anxiety disorders. The efficacy of antidepressants may be related to BDNF-TrkB signaling fueling neuroplastic changes. TrkB.T1 might have novel signaling effects that may be relevant for dealing with …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… the truncated tropomyosin receptor kinase B (TrkB) receptor. TrkB is the primary receptor for BDNF which is broadly expressed and released by neurons in developing and mature brain. TrkB has two predominant isoforms expressed in central nervous system (CNS), the full length TrkB (TrkB.FL) …
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THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE
… transmission to tropomyosin receptor kinase B (TrkB) at the motor neuron axon terminal causes clathrin mediated endocytosis of the complex and an intracellular signaling cascade that recruits dynein motor proteins for retrograde transport of the BDNF/TrkB endosome to the motor neuron soma. At …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… genes in SOX2-high tumours, and identified TrkB (encoded by the *NTRK2* gene) as a potential drug target candidate. Expression of TrkB correlated with SOX2 expression in squamous tumours, showed a functional role in squamous cancers, and *NTRK2* was confirmed as a transcriptional target of …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… increased signaling through presynaptic TrkB receptors in Schaffer collateral and mossy fiber axons. Estradiol effects on Akt signaling were associated with changes in spatial memory ability, and were profoundly altered in mice expressing the BDNF variant Val66Met. This study therefore …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… to modulate neuroplasticity. In Chapter 2, the TrkB receptor as a potential target for pharmacological modulation is examined. Its signaling, role in brain disease, and reported agonists and antagonists are reviewed. In addition, our attempts at establishing an assay to assess TrkB activation, …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… presence of the tropomyosin receptor kinase B (TrkB). TrkB is not normally found in sympathetic nervous tissue, which is the tissue NB develops from, and thus is a potential target for imaging and therapy. The presence of TrkB and its neurotrophin, brain derived neurotrophic factor (BDNF), have …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
… neurons. Like trkA, neuronal expression of trkB and trkC mRNA is reduced following axotomy, suggesting a neurotrophin-deficient state and a role for these molecules in promoting normal phenotype. Secondly, neuronal BDNF was characterized in intact, axotomized and NGF-infusedDRG using 'in …
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… ανοσοδραστικότητα για τους υποδοχείς TrkA (57%), TrkB (56%) και TrkC (46%). Όλα τα ολιγοδενδρογλοιώματα και τα επενδυμώματα που εξετάσθηκαν ήταν αρνητικά για τους υποδοχείς Trk ενώ έκφραση των υποδοχέων ανιχνεύθηκε σε μικρό ποσοστό των μυελοβλαστωμάτων. Στις ανοσοθετικές περιοχές των όγκων, το …
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