Isolation and Characterization of Bioactive Metabolites from Endophytic Fungi of Pinus Strobus

Fungal foliar endophytes of Pinus strobus (Eastern white pine) were collected from different sites across south-eastern New Brunswick, Canada for screening of bioactive metabolite compounds. Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four dihydrobenzofurans derivatives (5-8), one xanthene derivative (9), and one polyoxygenated cyclohexene (10). Two of the dihydrobenzofurans compounds are new (7 and 8), while the other two (5 and 6) are reported here for the first time as natural products. Compound 4 is known as a starting material in the synthesis of fullerenes. The remaining compounds (2, 3, 9, and 10) are also new. Compounds (1, 2, and 5-9) displayed antibacterial activity against Bacillus subtilis. Additionally, the known antifungal compound griseofulvin was quantified by LC-MS/MS.

Name thesis:degree_name

Master of Science (M.Sc.)

Level thesis:degree_level

Master's

Discipline thesis:degree_discipline

Chemistry

Grantor dc:publisher

Carleton University

Year dc:date.issued

2014

Author dc:creator

• Richardson, Susan Nicole

Statement dc:rights

• Copyright © 2014 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.

Language dc:language.iso

en

DOI

10.22215/etd/2014-10329

OAI identifier oai:identifier

oai:carleton.scholaris.ca:20.500.14718/32552