{"id":{"repo_id":"carleton","oai_identifier":"oai:carleton.scholaris.ca:20.500.14718/32552"},"canonical_url":"https://search.dev.ndltd.org/etd/carleton/oai:carleton.scholaris.ca:20.500.14718/32552","repository":{"repo_id":"carleton","name":"Carleton University","base_url":"https://carleton.scholaris.ca/server/oai/request"},"display":{"title":"Isolation and Characterization of Bioactive Metabolites from Endophytic Fungi of Pinus Strobus","abstract":"Fungal foliar endophytes of Pinus strobus (Eastern white pine) were collected from different sites across south-eastern New Brunswick, Canada for screening of bioactive metabolite compounds. Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four dihydrobenzofurans derivatives (5-8), one xanthene derivative (9), and one polyoxygenated cyclohexene (10). Two of the dihydrobenzofurans compounds are new (7 and 8), while the other two (5 and 6) are reported here for the first time as natural products. Compound 4 is known as a starting material in the synthesis of fullerenes. The remaining compounds (2, 3, 9, and 10) are also new. Compounds (1, 2, and 5-9) displayed antibacterial activity against Bacillus subtilis. Additionally, the known antifungal compound griseofulvin was quantified by LC-MS/MS.","abstract_html":"Fungal foliar endophytes of Pinus strobus (Eastern white pine) were collected from different sites across south-eastern New Brunswick, Canada for screening of bioactive metabolite compounds. Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four dihydrobenzofurans derivatives (5-8), one xanthene derivative (9), and one polyoxygenated cyclohexene (10). Two of the dihydrobenzofurans compounds are new (7 and 8), while the other two (5 and 6) are reported here for the first time as natural products. Compound 4 is known as a starting material in the synthesis of fullerenes. The remaining compounds (2, 3, 9, and 10) are also new. Compounds (1, 2, and 5-9) displayed antibacterial activity against Bacillus subtilis. Additionally, the known antifungal compound griseofulvin was quantified by LC-MS/MS.","abstract_has_math":false,"creators":["Richardson, Susan Nicole"],"institution":"Carleton University","degree_name":"Master of Science (M.Sc.)","degree_level":"Master's","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-24T01:34:43Z","subjects":[],"languages":["en"],"rights":["Copyright © 2014 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. 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Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four dihydrobenzofurans derivatives (5-8), one xanthene derivative (9), and one polyoxygenated cyclohexene (10). Two of the dihydrobenzofurans compounds are new (7 and 8), while the other two (5 and 6) are reported here for the first time as natural products. Compound 4 is known as a starting material in the synthesis of fullerenes. The remaining compounds (2, 3, 9, and 10) are also new. Compounds (1, 2, and 5-9) displayed antibacterial activity against Bacillus subtilis. Additionally, the known antifungal compound griseofulvin was quantified by LC-MS/MS."]},{"key":"dc:title","label":"Title","values":["Isolation and Characterization of Bioactive Metabolites from Endophytic Fungi of Pinus Strobus"]}]}],"canonical_facts":{"dc:creator":["Richardson, Susan Nicole"],"dc:date.accessioned":["2025-04-08T17:45:35Z"],"dc:date.available":["2025-04-08T17:45:35Z"],"dc:date.issued":["2014"],"dc:description.abstract":["Fungal foliar endophytes of Pinus strobus (Eastern white pine) were collected from different sites across south-eastern New Brunswick, Canada for screening of bioactive metabolite compounds. Metabolite isolation and characterization of three bioactive strains yielded the dibenzofuran derivative porric acid C (1), one butyrolactone derivative (2), one glucopyranosol derivative (3), one furfuryl ether derivative (4), four dihydrobenzofurans derivatives (5-8), one xanthene derivative (9), and one polyoxygenated cyclohexene (10). 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