Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis

Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2009

Author dc:creator

• Kuter, David

Advisors dc:contributor.advisor

• Egan, Timothy J
• Chibale, Kelly

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/9562

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/9562