Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents

Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2002

Author dc:creator

• Haupt, Hayley Claire

Advisor dc:contributor.advisor

• Chibale, Kelly

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6974

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6974