{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/6974"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/6974","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents","abstract":"Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents.","abstract_html":"Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents.","abstract_has_math":false,"creators":["Haupt, Hayley Claire"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Chibale, Kelly"],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-22T22:23:23Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/6974","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Chibale, Kelly"]},{"key":"dc:creator","label":"Author","values":["Haupt, Hayley Claire"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-09-08T09:57:25Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-09-08T09:57:25Z"]},{"key":"dc:date.issued","label":"Date","values":["2002"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/6974"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: leaves 108-113."]},{"key":"dc:description.abstract","label":"Abstract","values":["Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents."]},{"key":"dc:title","label":"Title","values":["Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents"]}]}],"canonical_facts":{"dc:contributor.advisor":["Chibale, Kelly"],"dc:creator":["Haupt, Hayley Claire"],"dc:date.accessioned":["2014-09-08T09:57:25Z"],"dc:date.available":["2014-09-08T09:57:25Z"],"dc:date.issued":["2002"],"dc:description":["Bibliography: leaves 108-113."],"dc:description.abstract":["Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents."],"dc:identifier.uri":["http://hdl.handle.net/11427/6974"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:23Z"}