Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol

Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2003

Author dc:creator

• Mudzunga, Theophilus Thivhulawi

Advisor dc:contributor.advisor

• Gammon, David W

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6344

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6344