{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/6344"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/6344","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol","abstract":"Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents.","abstract_html":"Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents.","abstract_has_math":false,"creators":["Mudzunga, Theophilus Thivhulawi"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Gammon, David W"],"committee_chairs":[],"committee_members":[],"year":2003,"date_issued":"2003","date_published":"2003","updated_at":"2026-07-22T22:22:37Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/6344","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gammon, David W"]},{"key":"dc:creator","label":"Author","values":["Mudzunga, Theophilus Thivhulawi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-08-13T14:27:29Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-08-13T14:27:29Z"]},{"key":"dc:date.issued","label":"Date","values":["2003"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/6344"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: leaves 175-182."]},{"key":"dc:description.abstract","label":"Abstract","values":["Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents."]},{"key":"dc:title","label":"Title","values":["Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gammon, David W"],"dc:creator":["Mudzunga, Theophilus Thivhulawi"],"dc:date.accessioned":["2014-08-13T14:27:29Z"],"dc:date.available":["2014-08-13T14:27:29Z"],"dc:date.issued":["2003"],"dc:description":["Bibliography: leaves 175-182."],"dc:description.abstract":["Mycobacterium tuberculosis is the causative agent of tuberculosis and is a leading pathogenic cause of death worldwide. The rise of mycobacterial resistance to common antituberculars such as isoniazid and rifampicin, along with the lethal alliance of HIV and M. tuberculosis co-infection, has led to interest in developing novel, effective, non-toxic antituberculosis agents."],"dc:identifier.uri":["http://hdl.handle.net/11427/6344"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:22:37Z"}