Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity

An interfacial method was developed in order to investigate the role lipids might play in haemozoin biosynthesis. Infrared and X-ray diffraction measurements demonstrated that β-haematin, a synthetic counterpart of haemozoin, forms efficiently at pentanol/water, octanol/water and lipid/water interfaces, but to a lesser extent at toluene/water interface under physiological conditions of pH and temperature and does not form at all in the absence of the interface.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2007

Author dc:creator

• Mabotha, Tebogo E

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6326

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6326