Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 138 for “"Chloroquine"”.
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Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles
… by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and intact Plasmodium falciparum isolated …
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Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… pathway and compared to the effect of chloroquine and artemisinin on the same pathway. The effects of drug treatment on the morphology and haemoglobin levels in the parasites as well as localization of transport vesicles via immunofluorescence microscopy were determined. A series of …
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New mono and bimetallic chloroquine derivatives : synthesis and evaluation as antiparasitic agents
… have been synthesised (where L = chloroquine, ferroquine, N-(7-chloro-quinolin-4-yl)-N'-[2-( N”, N""-dimethylaminomethyl)ferrocenyl methyl]-ethane-1 ,2-diamine, 3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N"",N""-dimethylaminomethyl)-ferrocenylmethyl]urea). All …
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Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis …
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Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
… utilised the autophagy-lysosomal inhibitor Chloroquine (CQ) since this compound is currently in clinical trials for a variety of blood and solid cancers, including breast cancer. Here, the mechanisms of CQ and furthermore, the potential of combining this drug with metabolic targeting …
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The Use of Combinations of Chemosensitisers to Reverse Chloroquine Resistance in Mice infected with Malaria
… compounds are able to transiently alter chloroquine resistance via chemosensitisation, the phenomenon has never evolved beyond laboratory practice as a result of in vivo difficulties. Chemosensitising compounds either need to be administered at doses which are toxic to the host in order …
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Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents
… of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents.
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Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains
Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance proteins might be involved in the mechanism of resistance. …
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Quercetin and chloroquine synergistically induces cell death in glioma cells via the increase of Ca2+ and ROS levels
… We show herein that quercetin, a flavonoid, and chloroquine (CQ), an antimalarial drug, synergistically induce caspase-mediated apoptosis in T98G cells. Combined treatment with quercetin and CQ accumulated poly-ubiquitinated proteins and activated unfolded protein response (UPR) in these cells. …
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An investigation of privileged substructural motifs as templates for the discovery and design of chloroquine-resistance reversal agents
Includes bibliographical references (leaves 152-165).
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The antimalarial activity of Dicoma anomala and the chloroquine resistance reversing effects of Sclerocarya birrea on Plasmodium falciparum in vitro
… selectively enhance the in vitro accumulation of chloroquine in resistant strains of Plasmodium falciparum.
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Evaluation of antihistamines for in vitro antimalarial activity against Plasmodium falciparum
… activity and cause a marked reversal of chloroquine resistance in vitro and in vivo. Promising results have been demonstrated when chlorpheniramine was combined with chloroquine to reverse chloroquine resistance in two African studies (Sowunmi et al, 1997; Abok., 1997).Recently, …
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Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity
An interfacial method was developed in order to investigate the role lipids might play in haemozoin biosynthesis. Infrared and X-ray diffraction measurements demonstrated that β-haematin, a synthetic counterpart of haemozoin, forms efficiently at pentanol/water, octanol/water and lipid/water …
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Antimalarials based on the arylpiperazine privileged substructure
… to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the …
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