Development of candidate Human papillomavirus vaccines

The objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, were expressed in insect cells by recombinant baculovirus, and the resulting virus-like particles (VLPs) were tested with a panel of well-characterised monoclonal antibodies (Mabs).

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2003

Author dc:creator

• Varsani, Arvind

Advisors dc:contributor.advisor

• Rybicki, Ed
• Williamson, Anne-Lise

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/5970

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/5970